Redox and NF-κB signaling in osteoarthritis

P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
… Interaction between redox signaling and NF-κB transcription … (ROS) and NF-κΒ signaling
pathways have been implicated … contribution of redox and NF-κΒ signaling pathways and their …

The NF-κB signalling pathway in osteoarthritis

S Rigoglou, AG Papavassiliou - The international journal of biochemistry & …, 2013 - Elsevier
… to osteoarthritis (OA) onset and progression. Therefore, targeted strategies that interfere with
NF-κB … In this review, we discuss the involvement of NF-κB in OA pathogenesis and how …

NF-κB signaling pathways in osteoarthritic cartilage destruction

MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of … (NF-κB) transcription factor has long been recognized as a
disease-contributing factor and, thus, has become a therapeutic target for OA. Because NF-κB

Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway

L He, Y Pan, J Yu, B Wang, G Dai, X Ying - International …, 2021 - Elsevier
… As everyone knows, nuclear factor kappa B (NF-κB) is a dimer transcription factor that …
NF-κB signaling pathway via binding to corresponding receptor subunits, provoking a signaling

Inflammatory signaling in cartilage: MAPK and NF-κ B pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis

J Saklatvala - Current drug targets, 2007 - ingentaconnect.com
… in osteoarthritis is critically reviewed. The organisation of the core signal transduction …
It is important to bear in mind that osteoarthritis is probably not a single disease entity: it is …

Ghrelin protects against osteoarthritis through interplay with Akt and NFκB signaling pathways

R Qu, X Chen, W Wang, C Qiu, M Ban, L Guo… - The FASEB …, 2018 - Wiley Online Library
Osteoarthritis (OA) is a common chronic degenerative disease characterized by … Moreover,
suppression of the Akt signaling pathway and activation of NFκB signaling in chondrocytes …

A review of non-coding RNA related to NF-κB signaling pathway in the pathogenesis of osteoarthritis

T Feng, Q Wu - International Immunopharmacology, 2022 - Elsevier
NF-κB signalingNF-κB signaling pathway, which induces destruction of the articular joint,
leading to OA onset and progression. In this review, we discuss the involvement of NF-κB in …

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Y Ye, J Zhou - Frontiers in Endocrinology, 2023 - frontiersin.org
… Thus, NF-κB signaling has become a potential target, and inhibition of NF-κB signaling can
effectively ameliorate the pathological development of OA (10). Flavonoids, a class of natural …

In vivo identification and induction of articular cartilage stem cells by inhibiting NF-κB signaling in osteoarthritis

W Tong, Y Geng, Y Huang, Y Shi, S Xiang, N Zhang… - Stem Cells, 2015 - academic.oup.com
… and disclose whether the inhibition of NF-κB signaling can induce ACSCs activation thus …
the NF-κB pathway and potently impair the responsiveness of ACSCs, whereas the NF-κB

Malvidin attenuates pain and inflammation in rats with osteoarthritis by suppressing NF-κB signaling pathway

T Dai, K Shi, G Chen, Y Shen, T Pan - Inflammation Research, 2017 - Springer
… is to investigate the effects of Malvidin on osteoarthritis (OA). … no effective disease-modifying
osteoarthritis drugs (DMOADs) … Nuclear factor-kappa B (NF-κB) signaling pathway has been …