Exhaustively characterizing feasible logic models of a signaling network using answer set programming
… of logic modeling of signaling networks. These models have been applied recently to analyze
signal … In particular, given a network encoding our knowledge of signal transduction and a …
signal … In particular, given a network encoding our knowledge of signal transduction and a …
Systematic analysis of quantitative logic model ensembles predicts drug combination effects on cell signaling networks
… Given that primary HCC cells from a patient can be harvested and expanded in culture,42
our approach is feasible for generating signaling network models in individual patients, which …
our approach is feasible for generating signaling network models in individual patients, which …
[HTML][HTML] Learning Boolean logic models of signaling networks with ASP
… all possible conjunctions having such evidence by computing for each v ∈ V all possible …
/ 3 , all possible logical formulas in disjunctive normal form. That is, we represent a Boolean …
/ 3 , all possible logical formulas in disjunctive normal form. That is, we represent a Boolean …
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
J Saez‐Rodriguez, LG Alexopoulos… - Molecular systems …, 2009 - embopress.org
… Next we created a superstructure of Boolean models having all possible logic gates compatible
with the compressed graph. The superstructure was represented as a hypergraph using …
with the compressed graph. The superstructure was represented as a hypergraph using …
Logic integer programming models for signaling networks
UU Haus, K Niermann, K Truemper… - Journal of …, 2009 - liebertpub.com
… The arising logic statements and integer … logic models reduce to a polynomial-time solvable
satisfiability algorithm. Additionally, a more dynamic model enables enumeration of possible …
satisfiability algorithm. Additionally, a more dynamic model enables enumeration of possible …
State–time spectrum of signal transduction logic models
A MacNamara, C Terfve, D Henriques… - Physical …, 2012 - iopscience.iop.org
… To illustrate the variety of logic modeling approaches, we will … network includes a subset of
intracellular signaling networks … to integrate as many network resources as possible. These …
intracellular signaling networks … to integrate as many network resources as possible. These …
[HTML][HTML] CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms
… logic models of signaling networks by training networks derived from prior knowledge to
signaling … of nodes states, which is possible using fuzzy logic models as introduced in[35] and …
signaling … of nodes states, which is possible using fuzzy logic models as introduced in[35] and …
[HTML][HTML] Designing experiments to discriminate families of logic models
S Videla, I Konokotina, LG Alexopoulos… - … in bioengineering and …, 2015 - frontiersin.org
… Logic models of signaling pathways are a promising way of … functional models of a cell, in
particular of signaling pathways. … the 1630 possible) to identify a family of logic models with a …
particular of signaling pathways. … the 1630 possible) to identify a family of logic models with a …
Boolean modeling: a logic‐based dynamic approach for understanding signaling and regulatory networks and for making useful predictions
… A Boolean or logic model characterizes each biomolecule by … models of signaling networks
with sustained input signals by … motifs and network simplification leads to one of two possible …
with sustained input signals by … motifs and network simplification leads to one of two possible …
[HTML][HTML] A logic-based method to build signaling networks and propose experimental plans
A Rougny, P Gloaguen, N Langonné, E Reiter… - Scientific Reports, 2018 - nature.com
… , and it is possible to make explicit the general rules used to interpret results obtained from
various types of experiments in order to automate the construction of signaling networks. …
various types of experiments in order to automate the construction of signaling networks. …
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