βcatenin signaling and cancer

PJ Morin - Bioessays, 1999 - Wiley Online Library
… Additional signaling functions were suggested for ß-catenin when the gene was cloned and
… in the wingless signaling pathway in Drosophila.(3) The signaling activity of ß-catenin is …

The Wnt/β-catenin signaling pathway as a target in drug discovery

F Takahashi-Yanaga, T Sasaguri - Journal of pharmacological …, 2007 - jstage.jst.go.jp
… Wnt/β-catenin signaling pathway (canonical pathway) Among the four Wnt signaling pathways,
the Wnt/βcatenin signaling pathway … to activate this signaling pathway. The activity of this …

Wnt/β-catenin signaling

T Akiyama - Cytokine & growth factor reviews, 2000 - Elsevier
β-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family
… of the Wnt signaling pathway. Furthermore, mutations in APC or β-catenin have been found …

Wnt–β-catenin signaling

KM Cadigan - Current Biology, 2008 - cell.com
… different signaling pathways, many act by regulating the stability and subcellular localization
of β-catenin. This intensively studied signal cascade is known as the Wnt–β-catenin pathway

Targeting the Wnt/β-catenin signaling pathway in human cancers

H Yao, E Ashihara, T Maekawa - Expert opinion on therapeutic …, 2011 - Taylor & Francis
… , the non-canonical planar cell polarity (PCP) pathway and the Wnt/Ca 2+ pathway Citation[1…
Wnt/β-catenin signaling pathway. The control of the Wnt/β-catenin signaling pathway occurs …

Wnt/β-catenin signaling: components, mechanisms, and diseases

BT MacDonald, K Tamai, X He - Developmental cell, 2009 - cell.com
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator
β-catenin … Here we review recent progress in this so-called canonical Wnt signaling pathway. …

Wnt/β-catenin pathway

RT Moon - Science's STKE, 2005 - science.org
… modifiers of the pathway are likely. In the absence of a Wnt signal, cytoplasmic β-catenin is
phosphorylated and … Wnt signaling pathways often work in a combinatorial manner with other …

Wnt/β-catenin signaling in development and disease

H Clevers - Cell, 2006 - cell.com
… . This review discusses how Wnt proteins are produced and secreted and how they activate
the canonical Wnt signaling pathway in recipient cells. Further, the review examines the …

Targeting the Wnt/β-catenin signaling pathway in cancer

Y Zhang, X Wang - Journal of hematology & oncology, 2020 - Springer
… Wnt/β-catenin and PI3K-AKT pathway was confirmed to … importance of Wnt/β-catenin signaling
pathway in tumorigenesis, … of Wnt/β-catenin signaling pathway targeted interventions in …

Wnt/β-catenin signaling pathway as novel cancer drug targets

HH Luu, R Zhang, RC Haydon… - Current cancer drug …, 2004 - ingentaconnect.com
… this pathway may play an important role in tumor development. Over the past 15 years, our
understanding of this signaling pathway … downstream targets of β-catenin/Tcf transactivation …