Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice

X Liu, H Zhu, H Gao, X Tian, B Tan, R Su - Biochemical and Biophysical …, 2022 - Elsevier
pathway To investigate the effects of G s signaling on HTR induced by 5-HT 2A R agonists,
… examine the role of G s signaling pathway in DOM-induced head twitch response. G s protein …

Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways

H Zhu, X Liu, X Wang, Y Li, F Ma, B Tan, P Zhou… - European Journal of …, 2023 - Elsevier
head twitches through visual examination for 30 min. Mice were pretreated with M100907
(10, 50, 100 and 1000 μg/kg, ip) 15 min prior to DOM administration (2.5 mg/kg, ip) to study the …

Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway

H Gao, X Liu, L Xie, B Tan, R Su - Neurochemical Research, 2024 - Springer
… Given that G s signaling pathway was demonstrated to play a … the role of G s signaling
pathway in how mGluR2 agonist … 5-HT 2A R-mediated G s signaling pathway (Fig. 7a). DOM-…

Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement

AL Halberstadt, MA Geyer - Psychopharmacology, 2013 - Springer
… to analyze the head movement that occurs during head twitches in C57BL/6J mice. Experiments
were also conducted in C57BL/6J mice to determine whether a head-mounted magnet …

Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice

AM Jaster, J Younkin, T Cuddy… - Neuroscience …, 2022 - Elsevier
signaling pathways involved in their hallucinogenic properties. Importantly, more recent
clinical trials suggest that psychedelics may represent a promising novel treatment strategy for …

Headtwitch response in rodents induced by the hallucinogen 2, 5‐dimethoxy‐4‐iodoamphetamine: a comprehensive history, a re‐evaluation of mechanisms, and its …

CE Canal, D Morgan - Drug testing and analysis, 2012 - Wiley Online Library
… touch near the back of the head, similar to the reflexive response … and violent head shaking…
The head-twitch response does … a particular animal possesses the head twitch or not….…

Serotonin 2C receptors are also important in head-twitch responses in male mice

RJP Custodio, DM Ortiz, HJ Lee, LV Sayson, M Kim… - …, 2023 - Springer
… The frontal cortex-dependent head-twitch response … signaling through G protein-dependent
(through its sub-classes: G s , G i/o , G q/11 , and G 12/13 ) and other -independent pathways

Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice

N Egashira, A Shirakawa, R Okuno, K Mishima… - Pharmacology …, 2011 - Elsevier
… We previously reported that systemic administration of the endocannabinoid
anandamide inhibited the head-twitches induced by the hallucinogenic drug 2,5-dimethoxy-4-…

Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT) 2A receptors in the …

N Egashira, K Iwasaki, A Ishibashi, K Hayakawa… - Progress in Neuro …, 2008 - Elsevier
Head-twitch response is a distinctive twitching behavior of the head. The procedure followed
… Hallucinogens recruit specific cortical 5-HT 2A receptor-mediated signaling pathways to …

The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen

CE Canal, UB Olaghere da Silva, PJ Gresch… - …, 2010 - Springer
… 5-HT 2C receptor density in the brains of C57BL/6J and DBA/2J was also equivalent,
suggesting that 5-HT 2C receptor-mediated intracellular signaling or other physiological …