EGFR signaling pathway as therapeutic target in human cancers

E Levantini, G Maroni, M Del Re, DG Tenen - Seminars in Cancer Biology, 2022 - Elsevier
Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance of epithelial
tissues. However, when EGFR signaling is altered, it becomes the grand orchestrator of …

Sphingosine-1-phosphate (S1P) and S1P signaling pathway: therapeutic targets in autoimmunity and inflammation

HC Tsai, MH Han - Drugs, 2016 - Springer
… transporter) are also potential targets for treatment of autoimmune diseases. Finally, the
application of therapies targeting S1P and S1P signaling pathways may be expanded to treat …

Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma

M Dimri, A Satyanarayana - Cancers, 2020 - mdpi.com
… has led to the identification of novel therapeutics for HCC … of the signaling pathways involved
in the development and initiation of HCC and anticipate the potential targets for therapeutic

Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - … and targeted therapy, 2022 - nature.com
signaling pathways play an important role in administering the process of MI, aiming at targeting
these aberrant signaling pathwaystherapy, gene therapy, protein therapy, cell therapy, …

Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma

M Kudo - Digestive Diseases, 2011 - karger.com
signaling pathways, and the VEGFR and PDGFR signaling … in HCC, and agents targeting
these pathways are under … pathway has been extensively studied as a therapeutic target

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer

HX Li, JF Zeng, K Shen - Archives of gynecology and obstetrics, 2014 - Springer
… AKT serves as a central sensor in the PI3K pathway and represents an attractive therapeutic
target since multiple signaling components converge in AKT. There are three isoforms of …

Signaling pathways in cancer: therapeutic targets, combinatorial treatments, and new developments

HYK Yip, A Papa - Cells, 2021 - mdpi.com
… Nowadays, signaling pathways and molecular networks are recognized for their critical …
a few signaling pathways and on selected types of cancer for which targeted therapies have …

Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease

G Wang, J Pan, SD Chen - Progress in neurobiology, 2012 - Elsevier
… Inhibitors of the ERK signaling pathway, which plays an … and their related phosphorylation
signaling pathways (JNK, ERK, … signaling pathways will reveal potential therapeutic targets for …

The Role of TGF‐β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

Y Yang, WL Ye, RN Zhang, XS He… - Evidence‐Based …, 2021 - Wiley Online Library
… its potential as a therapeutic target. We first introduce the related role of this signaling pathway
in tumorigenesis and development. Then, using the classic TGF-β signaling pathway as a …

The Wnt signaling pathway: a potential therapeutic target against cancer

N Ghosh, U Hossain, A Mandal… - Annals of the New York …, 2019 - Wiley Online Library
… Hence, deregulation of the Wnt pathway across several … therapeutic target; however, attempts
to target Wnt signaling have been difficult to realize due to the complexity of the pathways. …