… TGF-β/Smad signaling pathway on the tubulointerstitial fibrosis and highlighted the therapeutic
… TGF-β/Smad pathway against tubulointerstitial fibrosis. 2 TGF-β/Smad Signaling Pathway …

… Wnt/β-catenin signaling pathway could activate renal fibrosis-… in the fibrosis process, and
improve renal fibrosis. Therefore, … the Wnt/β-catenin signaling pathway on this basis to further …

… that tubulointerstitial fibrosis and … and its signaling pathway in the kidney. These results
indicate that deletion of PKC-ε mediates renal fibrosis and that TGF-β1 and its signaling pathway …

… signaling pathways.3, 4 Canonical TGF-β signaling is mediated by the Smads, but other
downstream proteins (eg, mitogen-activated protein kinase, TGF-beta activated kinase) can …

… effect in ameliorating renal tubulointerstitial fibrosis, and this activity possibly via suppression
of the TGF-β and its downstream regulatory signaling pathway, including Smad2/3. …

… the Hippo signaling pathway plays a pivotal role in the development of renal fibrosis. We …
TAZ activation in the Hippo signaling pathway as regulators of fibrosis in CKD because the …

… of autophagy in renal tubulointerstitial fibrosis. We showed … signaling pathway, which in
turn induced EMT-like phenotype changes and led to accelerated renal tubulointerstitial fibrosis …

… (TGF)-β signaling pathway is known to play a pivotal role in the renal tubulointerstitial fibrosis
[5, 6… Smad family and non-canonical TGF-β signaling pathways [7]. Canonical TGF-β/Smad …

… Tubulointerstitial fibrosis is considered as the final common pathway for all chronic kidney
… Recent studies have demonstrated that a key step in tubulointerstitial fibrosis is epithelial-…

… fibrosis signals and attenuates renal tubulointerstitial fibrosis during the aging process. We
observed that the TGF- β/Smads signal pathway … TGF- β/Smads signaling. We further showed …