… these signaling networks may affect tumor response to therapy. This review summarizes the
state of knowledge about signaling pathways … that underlie dysregulation of these pathways. …

The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across
multiple species. Its activity is reduced or absent in adult organisms. However, activation of the …

… was found in 17 of 29 clear cell carcinomas (59%), of which 14 … the mTOR signaling pathway
in clear cell renal cell carcinoma … Two of 3 renal clear cell carcinoma derived cell lines also …

… and are enriched in activation of canonical WNT signaling. Here, we review the main
signaling pathways deregulated in HCC and how they have been exploited therapeutically. …

… LeTx also showed direct inhibition of proliferation of endothelial cells in vitro. Our results
suggest that suppression of one or more MAPK signaling pathways may inhibit RCC growth …

… Other pathways related to cell differentiation have also been … of emerging altered signaling
pathways involved in HCC and … lesscharacterized pathways involved in cell differentiation, …

… major molecular signaling pathways implicated in the pathogenesis of HCC. In addition,
we explore the rationale for targeting molecular components of these signaling pathways, …

… classical signaling pathways which have been proved in other cancer types but not in
LSCC, including PI3K signaling pathway, VEGF/VEGFR signaling, and CDK4/6 pathway. Other …

… signaling pathway, the ubiquitin/proteasome degradation and the hedgehog signaling pathway
has … In this review, we elaborated on our current understanding of the signaling pathways …

… of the cellular origin of HCC, the structural damage and genomic mutations in HCC, as well
as the most relevant signaling pathways … in the context of their respective signaling pathways. …