… of large-scale signaling systems. This analysis focuses on the structure of signaling networks;
future work will need to account for compartmentalization of signaling events, as well as …

… analyses of signalling networks are limited, owing to a lack of corresponding reconstructions.
Recent work by our group involved the analysis of network features … ) signalling network 97 …

… such as integration of signals across multiple time scales, … These properties of signaling
networks raise the possibility that … biochemical reactions that comprise signaling pathways. …

… The lining of the urinary tract, the urothelium, has attributes that make it of particular
interest to this study. Urothelium cells in vivo multiply slowly but they have a fast proliferative …

… In principle, similar features are of interest also for signaling … their opposite meanings we
often need to analyze them separately in statistical assessments. Second, in metabolic networks …

… We have used computational analysis to study emergent properties of simple networks
that consist of up to four pathways, We find that when one pathway gates signal flow through …

… A valid model can then be analyzed to obtain predictions about any novel properties and
higher order cellular capabilities that the signaling network may possess. This can be done by …

… can be transformed into logic-based ODEs enabling studies on essential quantitative and
dynamic features of a signaling network, where time and states are continuous. …

… properties of hubs and bottlenecks in protein–protein interaction networks with implications
in signalling, … proteins and, consequently, the literature regarding such networks is extensive. …

… from computer science to study signalling networks constitutes an … Cell signalling networks
(CSNs) represent a class of … as metabolic networks) by an arrangement of special properties. …