Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
disease progression in the brain remain largely unknown. To better understand the pathological
… , and atrophy correlated with severity of brain Aβ pathology, tauopathy, and atrophy, and …

[HTML][HTML] Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease

A Dincer, BA Gordon, A Hari-Raj, SJ Keefe, S Flores… - NeuroImage: Clinical, 2020 - Elsevier
… a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD)
pathology … Since late-onset Alzheimer disease (LOAD) participants tend to have age-related …

Brain metabolic signatures across the Alzheimer's disease spectrum

A Sala, C Caprioglio, R Santangelo, EG Vanoli… - European journal of …, 2020 - Springer
… We identified hypometabolism signatures for each clinical atypical variant within the AD …
paradigm of neurodegenerative disease, positing that the pathology associated with these …

A machine learning approach to identify a circulating MicroRNA signature for Alzheimer disease

X Zhao, J Kang, V Svetnik, D Warden… - The journal of …, 2020 - academic.oup.com
Alzheimer disease (AD) diagnosis. Our results indicate that the serum microRNA signature
Alzheimer disease (AD) 6 is the most common form of dementia with increasing prevalence …

Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

BC Dickerson, TR Stoub, RC Shah, RA Sperling… - Neurology, 2011 - AAN Enterprises
… consistent with very early AD pathology could be detected in … ) collectively called the cortical
signature of AD based on our … Figure 3 Alzheimer disease (AD)-signature MRI biomarker …

A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets

JA Roberts, VR Varma, Y An, S Varma, J Candia… - Science …, 2021 - science.org
signature. In steps 3 and 4, we tested associations between the incipient AD proteomic
signature and both AD pathologypathology. In step 6b, we validated the incipient AD proteomic …

[HTML][HTML] Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?

R Mc Ardle, B Galna, P Donaghy, A Thomas… - Alzheimer's & …, 2019 - Elsevier
… We present early evidence for unique pathological signatures of gait in AD and LBD from …
findings provide initial evidence that Alzheimer's disease and Lewy body disease have unique …

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

F Di Domenico, G Pupo, E Giraldo, MC Badìa… - Free Radical Biology …, 2016 - Elsevier
… Several studies suggest that pathological changes in Alzheimer’s disease (AD) brain begin
around 10–20 years before the onset of cognitive impairment. Biomarkers that can support …

Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer's disease

MT Lynch, MA Taub, JM Farfel, J Yang, P Abadir… - Scientific reports, 2023 - nature.com
… 34,36 to understand the effect of multiple genomic signatures of aging on clinical and pathologic
features of AD, other neurodegenerative diseases, and cerebrovascular disease (CVD). …

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

DJ Irwin, TJ Cohen, M Grossman, SE Arnold, SX Xie… - Brain, 2012 - academic.oup.com
… , and also thioflavin-S-negative pathology in corticobasal degeneration and progressive …
of Alzheimer's disease pathology, but was more prominently associated with pathological tau …