Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults

J Popp, A Oikonomidi, D Tautvydaitė, L Dayon… - Brain, behavior, and …, 2017 - Elsevier
… that the inflammatory biomarker signatures may be particularly … that inflammatory biomarker
signatures may improve the … impairment due to Alzheimer's disease: recommendations from …

The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

EM Arenaza-Urquijo, SA Przybelski, TL Lesnick… - Brain, 2019 - academic.oup.com
… cognition and FDG in Alzheimer's disease signature regions. … with high Alzheimer’s disease
pathology and APOE E4 carriage… of Alzheimer’s disease pathology and in APOE E4 carriers. …

The complexities of the pathology–pathogenesis relationship in Alzheimer disease

RJ Castellani, G Perry - Biochemical pharmacology, 2014 - Elsevier
… setting of Alzheimer's disease (AD). … pathology, these analyses will necessarily suffer from
the same uncertainties that are inherent in pathologic examination, namely that AD pathology

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

M Wang, P Roussos, A McKenzie, X Zhou, Y Kajiwara… - Genome medicine, 2016 - Springer
… , including correlations between module eigengenes and cognitive/pathological traits, and
enrichment for gene expression signatures such as the DEGs and TCGs calculated above. To …

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease

R Freer, P Sormanni, G Vecchi, P Ciryam… - Science …, 2016 - science.org
… Because this expression signature is evident in healthy brains, our analysis provides an …
risk of protein aggregation and a corresponding vulnerability to Alzheimer’s disease. …

Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology

B Guennewig, J Lim, L Marshall, AN McCorkindale… - Scientific Reports, 2021 - nature.com
… of tau and Aβ pathology in the absence of neuronal loss meant that ‘sick’ or dysfunctional
neurons would contribute substantially to the disease transcriptomic signature. A second …

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease

JP Ferrari-Souza, PCL Ferreira, B Bellaver… - Molecular …, 2022 - nature.com
… We observed an indirect effect of Aβ pathology on cognition through higher CSF GFAP
levels and … Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis. …

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

P Ciryam, R Kundra, R Freer… - Proceedings of the …, 2016 - National Acad Sciences
… The presence of such aberrant aggregate species generates a cascade of pathological
events, … meta-analyses carried out in this work for Alzheimer's disease and clinical depression …

Blood protein signature for the early diagnosis of Alzheimer disease

M Britschgi, T Wyss-Coray - Archives of neurology, 2009 - jamanetwork.com
… Although it is still unclear how the studies in mice with AD-like pathological features relate
to the human disease, our findings in plasma of patients with AD offer a framework to study the …

Uncovering biologically coherent peripheral signatures of health and risk for Alzheimer's disease in the aging brain

…, Alzheimer's Disease Neuroimaging Initiative - Frontiers in aging …, 2018 - frontiersin.org
… on risk for Alzheimer’s disease (AD). We examined 829 participants (M age : 75.3 ± 6.9 years;
350 women and 479 men) from the Alzheimer’s Disease Neuroimaging Initiative database …