Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults
… that the inflammatory biomarker signatures may be particularly … that inflammatory biomarker
signatures may improve the … impairment due to Alzheimer's disease: recommendations from …
signatures may improve the … impairment due to Alzheimer's disease: recommendations from …
The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies
EM Arenaza-Urquijo, SA Przybelski, TL Lesnick… - Brain, 2019 - academic.oup.com
… cognition and FDG in Alzheimer's disease signature regions. … with high Alzheimer’s disease
pathology and APOE E4 carriage… of Alzheimer’s disease pathology and in APOE E4 carriers. …
pathology and APOE E4 carriage… of Alzheimer’s disease pathology and in APOE E4 carriers. …
The complexities of the pathology–pathogenesis relationship in Alzheimer disease
RJ Castellani, G Perry - Biochemical pharmacology, 2014 - Elsevier
… setting of Alzheimer's disease (AD). … pathology, these analyses will necessarily suffer from
the same uncertainties that are inherent in pathologic examination, namely that AD pathology …
the same uncertainties that are inherent in pathologic examination, namely that AD pathology …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
… , including correlations between module eigengenes and cognitive/pathological traits, and
enrichment for gene expression signatures such as the DEGs and TCGs calculated above. To …
enrichment for gene expression signatures such as the DEGs and TCGs calculated above. To …
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease
… Because this expression signature is evident in healthy brains, our analysis provides an …
risk of protein aggregation and a corresponding vulnerability to Alzheimer’s disease. …
risk of protein aggregation and a corresponding vulnerability to Alzheimer’s disease. …
Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology
B Guennewig, J Lim, L Marshall, AN McCorkindale… - Scientific Reports, 2021 - nature.com
… of tau and Aβ pathology in the absence of neuronal loss meant that ‘sick’ or dysfunctional
neurons would contribute substantially to the disease transcriptomic signature. A second …
neurons would contribute substantially to the disease transcriptomic signature. A second …
Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease
… We observed an indirect effect of Aβ pathology on cognition through higher CSF GFAP
levels and … Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis. …
levels and … Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis. …
A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation
… The presence of such aberrant aggregate species generates a cascade of pathological
events, … meta-analyses carried out in this work for Alzheimer's disease and clinical depression …
events, … meta-analyses carried out in this work for Alzheimer's disease and clinical depression …
Blood protein signature for the early diagnosis of Alzheimer disease
M Britschgi, T Wyss-Coray - Archives of neurology, 2009 - jamanetwork.com
… Although it is still unclear how the studies in mice with AD-like pathological features relate
to the human disease, our findings in plasma of patients with AD offer a framework to study the …
to the human disease, our findings in plasma of patients with AD offer a framework to study the …
Uncovering biologically coherent peripheral signatures of health and risk for Alzheimer's disease in the aging brain
…, Alzheimer's Disease Neuroimaging Initiative - Frontiers in aging …, 2018 - frontiersin.org
… on risk for Alzheimer’s disease (AD). We examined 829 participants (M age : 75.3 ± 6.9 years;
350 women and 479 men) from the Alzheimer’s Disease Neuroimaging Initiative database …
350 women and 479 men) from the Alzheimer’s Disease Neuroimaging Initiative database …