… Although it is still unclear how the studies in mice with AD-like pathological features relate
to the human disease, our findings in plasma of patients with AD offer a framework to study the …

… on risk for Alzheimer’s disease (AD). We examined 829 participants (M age : 75.3 ± 6.9 years;
350 women and 479 men) from the Alzheimer’s Disease Neuroimaging Initiative database …

… Using the gene expression profiles from Alzheimer's disease and control subjects and their
… , intrinsic and coordinated gene expression signatures due to disease pathology in the high-…

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a …

… Herein, we demonstrated that signatures relying on prediction of progression within 2 and 3
… Recently, 2 candidate signatures of progression to AD were proposed. These studies were, …

… and biochemical research of the Alzheimer's disease. We also discuss the latest and most
significant results that will help to define a specific disease signature whose validity might be …

… The utility of our microglial signature derived herein was … number and activation state
in aging and Alzheimer's disease. … vulnerability and progression of Alzheimer's pathology. …

… We included 127 Alzheimer's disease (AD) patients and 121 control subjects with cerebrospinal
fluid … Multiple signatures were assessed: differential expression (nested linear models), …

… 3) and an area known to be susceptible to AD pathology (middle temporal gyrus, BA 21). We
… the consequences of diagnostic plaque and tangle pathology, but preceded it and thus may …

… onset of pathology [1, 12]. Our study characterized the transcriptome signature of whole Bm-…
transcriptomic dysregulation and pathology and the complexity of gene regulatory control of …