Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer's disease: the Altoida large cohort study

IB Meier, M Buegler, R Harms, A Seixas… - NPJ Digital …, 2021 - nature.com
… assessments for Alzheimer’s disease are burdensome and inaccurate at detecting mild
cognitive impairment and predicting Alzheimer’s disease risk. Altoida’s Digital Neuro Signature (…

Detection of Alzheimer's disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosis

…, Alzheimer's Disease Neuroimaging Initiative - Human brain …, 2015 - Wiley Online Library
… A strong similarity with AD pathological patterns indicates the presence of an AD MRI
signature and thus reveals that the neurodegeneration process related to AD has started. This …

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

EM Blalock, HM Buechel, J Popovic, JW Geddes… - Journal of chemical …, 2011 - Elsevier
Alzheimer's disease (AD) is a devastating … disease's critical early stages. In a prior microarray
study we correlated gene expression in hippocampus with degree of Alzheimer's disease

The paradox of syndromic diversity in Alzheimer disease

JD Warren, PD Fletcher, HL Golden - Nature Reviews Neurology, 2012 - nature.com
… According to this interpretation, the network signatures … : how does the single pathological
entity of AD give rise to … disease, the pathology associated with these disease variants is …

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease

E Gkanatsiou, E Portelius, CE Toomey, K Blennow… - Neuroscience …, 2019 - Elsevier
… Aβ plaque pathology only and subjects with Aβ plaque pathology together with CAA pathology.
… This information may be useful in the development of pathology-specific biomarkers. …

A blood based 12-miRNA signature of Alzheimer disease patients

P Leidinger, C Backes, S Deutscher, K Schmitt… - Genome biology, 2013 - Springer
Alzheimer disease (AD) is the most common form of … We present a novel miRNA-based
signature for detecting AD … Using this 12-miRNA signature, we differentiate between AD and …

Linking hypothetical knowledge patterns to disease molecular signatures for biomarker discovery in Alzheimer's disease

A Malhotra, E Younesi, S Bagewadi… - Genome medicine, 2014 - Springer
… of hypotheses related to particular stages of Alzheimer's disease from Medline abstracts. …
efficient diagnosis of the disease is important not only to rule out non-AD pathology but also to …

Detection of Alzheimer disease (AD)-specific tau pathology in AD and nonAD tauopathies by immunohistochemistry with novel conformation-selective tau antibodies

GS Gibbons, RA Banks, B Kim… - … of Neuropathology & …, 2018 - academic.oup.com
… beta sheet structure forming pathological aggregates believed to cause … is a pathological
hallmark of Alzheimer disease (AD) and … heterogeneous neurodegenerative diseases including …

Application of immunosignatures to the assessment of Alzheimer's disease

L Restrepo, P Stafford, DM Magee… - Annals of …, 2011 - Wiley Online Library
… Using antibodies to different forms of Aβ peptide and blocking protocols, we demonstrate
that most of this signature is not due to the subject's antibodies raised against Aβ. …

Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease

A Nakamura, P Cuesta, A Fernández, Y Arahata… - Brain, 2018 - academic.oup.com
signatures that may act as surrogate markers of the pathophysiological changes that occur in
the predementia stages of Alzheimer’s disease. Further… of potential MEG signatures, we first …