[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
… overview of currently available computational models for cardiomyocyte Ca 2+ handling.
Finally, … cardiomyocyte Ca 2+ handling and highlight how synergy between in vitro and in silico …
Finally, … cardiomyocyte Ca 2+ handling and highlight how synergy between in vitro and in silico …
Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology
… Here, we present a computer model that simulates the time course of intracellular Ca 2+
concentration and its interplay with diverse ion currents during T cell activation. We used a …
concentration and its interplay with diverse ion currents during T cell activation. We used a …
Competitive Tuning Among Ca2+/Calmodulin-Dependent Proteins: Analysis of In Silico Model Robustness and Parameter Variability
… First we compare dynamic model output of two models: a two-state model of Ca 2+ /CaM
binding and a four-state model of Ca 2+ /CaM binding. We find that a four-state model of Ca 2+ /…
binding and a four-state model of Ca 2+ /CaM binding. We find that a four-state model of Ca 2+ /…
[HTML][HTML] In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes
BI Iaparov, I Zahradnik, AS Moskvin… - Journal of General …, 2021 - rupress.org
… in silico simulations on a large set of models of calcium release sites (CRSs). Our models …
, with an open probability dependent on concentrations of free Ca 2+ and Mg 2+ ions, in a …
, with an open probability dependent on concentrations of free Ca 2+ and Mg 2+ ions, in a …
Stochastic models for the in silico simulation of synaptic processes
A Bracciali, M Brunelli, E Cataldo, P Degano - BMC bioinformatics, 2008 - Springer
… + fluorescent indicator gives an indication of the real Ca 2+ sensed by the vesicles. This …
model for the process of the Ca 2+ triggered vesicle release. Also, one can infer local Ca 2+ …
model for the process of the Ca 2+ triggered vesicle release. Also, one can infer local Ca 2+ …
Computer modeling of hippocampal CA1 pyramidal cells-a tool for in silico experiments
… an in silico tool in the experimental laboratories. To be useful in neuroscience labs, the
modeling … Poirazi and Royeck implemented a detailed model of Ca2+ dynamics, the Shah model …
modeling … Poirazi and Royeck implemented a detailed model of Ca2+ dynamics, the Shah model …
In silico assessment of genetic variation in PITX2 reveals the molecular mechanisms of calcium-mediated cellular triggered activity in atrial fibrillation
… We showed a higher density of SCaEs and content of SR Ca2+ in atrial myocytes with
the rs13143308T risk variant. Further computational analysis revealed that these calcium-…
the rs13143308T risk variant. Further computational analysis revealed that these calcium-…
In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
… Notably, the elevated function of calcium transport ATPase increases sarcoplasmic reticulum
Ca 2+ concentration, thereby enhancing susceptibility to triggered activity. Furthermore, …
Ca 2+ concentration, thereby enhancing susceptibility to triggered activity. Furthermore, …
In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy
… Methods: We adapted a computer model of mouse ventricular electrophysiology using …
A population-of-models approach was used to investigate the generalizability of our findings…
A population-of-models approach was used to investigate the generalizability of our findings…
Computational models for calcium-mediated astrocyte functions
T Manninen, R Havela, ML Linne - Frontiers in computational …, 2018 - frontiersin.org
… We considered in the present study only models where astrocytic Ca 2+ … the roles of
astrocytes in neural network dynamics. Based on our evaluation, we found out that in silico models …
astrocytes in neural network dynamics. Based on our evaluation, we found out that in silico models …