[HTML][HTML] Enhancing TCR specificity predictions by combined pan-and peptide-specific training, loss-scaling, and sequence similarity integration
MF Jensen, M Nielsen - Elife, 2024 - elifesciences.org
… response is the recognition of peptides presented by MHC (Major … the extreme variety of
peptides presented by the MHC, the … of the negative prediction scores for the given peptide for all …
peptides presented by the MHC, the … of the negative prediction scores for the given peptide for all …
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification
M Andreatta, E Karosiene, M Rasmussen, A Stryhn… - Immunogenetics, 2015 - Springer
… produces a reliability score for the optimal register of each predicted binder as part of its
prediction. For the 51 peptide-MHCs in Tables 1 and 2, sorted by reliability scores, we observe …
prediction. For the 51 peptide-MHCs in Tables 1 and 2, sorted by reliability scores, we observe …
[HTML][HTML] An analysis of natural T cell responses to predicted tumor neoepitopes
… Thus, the final dataset included 1,948 peptide-MHC … the average similarity between a set
of 9-mer peptide pairs with … by a lower self-similarity score compared to IB neoepitopes (P = …
of 9-mer peptide pairs with … by a lower self-similarity score compared to IB neoepitopes (P = …
Ab initio prediction of peptide‐MHC binding geometry for diverse class I MHC allotypes
AJ Bordner, R Abagyan - Proteins: Structure, Function, and …, 2006 - Wiley Online Library
… In contrast, physics-based scoring functions combined with … peptide lengths and MHC
allotypes, for use in vaccine design. … residues, which cause the peptide backbone to adopt similar …
allotypes, for use in vaccine design. … residues, which cause the peptide backbone to adopt similar …
Rapid, precise, and reproducible prediction of peptide–MHC binding affinities from molecular dynamics that correlate well with experiment
… with additional details about the score and the social media … similar training data are
unavailable for a specific MHC allele, … of 12 diverse peptides bound by a class I MHC molecule …
unavailable for a specific MHC allele, … of 12 diverse peptides bound by a class I MHC molecule …
Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach
M Nielsen, C Lundegaard, P Worning, CS Hvid… - …, 2004 - academic.oup.com
… find promiscuous peptides that bind to a series of MHC variants… of a peptide was calculated
as the score of the highest scoring … that a similar approach can be applied to the MHC class II …
as the score of the highest scoring … that a similar approach can be applied to the MHC class II …
[HTML][HTML] Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method
… on MHC ligand data (peptides eluted from MHC complexes … peptide score within the peptide,
where a nonamer peptide … We adopt a similar approach, to improve the performance of …
where a nonamer peptide … We adopt a similar approach, to improve the performance of …
[HTML][HTML] Amino acid similarity accounts for T cell cross-reactivity and for “holes” in the T cell repertoire
… foreign and self-peptides are able to form peptide:MHC complexes (pMHC). Presentation of
… coefficients between their relative SFU and our peptide similarity score were: 0.40, 0.39, and …
… coefficients between their relative SFU and our peptide similarity score were: 0.40, 0.39, and …
MHCVision: estimation of global and local false discovery rate for MHC class I peptide binding prediction
… We can then estimate the PEP of an individual peptide’s predicted score, and conversely …
suggest that MHCflurry gives similar strong performance for peptide binding prediction; we thus …
suggest that MHCflurry gives similar strong performance for peptide binding prediction; we thus …
GibbsCluster: unsupervised clustering and alignment of peptide sequences
… peptide-MHC binding data (NetMHCIIpan), and concluded that the unsupervised clustering
gave solutions reasonably similar … assignment, scores and alignment core of each peptide. …
gave solutions reasonably similar … assignment, scores and alignment core of each peptide. …