… insufficient to fully describe pharmacodynamics, as temporal … present the minimum model
that can simultaneously deal with … pharmacokinetic models to yield a fully integrated model for …

… model We describe a variation on an approach to simultaneous modeling of
pharmacokinetics (PK) and pharmacodynamics (PD). Both approaches …

… that fits a largely non-parametric model to pharmacokinetic (PK) and pharmacodynamic (PD)
data; it … A PK model relates dose to plasma concentrations (Cp), a link model relates plasma …

Three models, linked in series, can be used to analyze combined pharmacokinetic (PK) and
pharmacodynamic (PD) … A PK model relates dose to plasma drug concentration (Cp); a link …

… AIM: To study the simultaneous modeling of phamacokinetics and pharmacodynamics (
PK-PD) of propafenone (Pro) in healthy subjects. METHODS, Ten healthy Chinese volunteers, 5 …

… Pharmacokinetic and pharmacodynamic data were simultaneously fitted to a semiparametric
model… the feasibility of conducting pharmacokinetic pharmacodynamic analysis during the …

… pharmacodynamic parameters by simultaneously modeling their pharmacokinetic-pharmacodynamic …
of their active metabolite(s) into the model wherever necessary. We have chosen …

… concentrations and subsequent ex vivo pharmacodynamics collected from a patient
population. The modeling technique used in this study allows for the simultaneous fitting of PK/PD …

This study compares the time course of triazolam effects on psychomotor and cognitive skills
with triazolam plasma concentrations in a combined pharmacokinetic-pharmacodynamic (…

… We have reported the pharmacokinetics of enantiomers of pimobendan in … pharmacodynamic
effect of pimobendan and a simultaneous pharmacokinetic-pharmacodynamic modeling. …