Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis–A clinicobiochemical study

HS Grover, S Kapoor, A Singh - Journal of oral biology and craniofacial …, 2016 - Elsevier
… in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local drug-delivery agent
on clinical parameters and on interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) …

Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic …

GG Vemanaradhya, S Emani, DS Mehta… - Archives of Oral …, 2017 - Elsevier
… Hence the present study was aimed at evaluating the efficacy of 1.2% simvastatin gel as
a LDD in adjunct to SRP on GCF IL-6 & IL-8 levels in chronic periodontitis patients and …

Simvastatin decreases IL-6 and IL-8 production in epithelial cells

K Sakoda, M Yamamoto, Y Negishi… - Journal of dental …, 2006 - journals.sagepub.com
… , we measured simvastatin effects on interleukin-6 and interleukin-8 production by cultured
human epithelial cell line (KB cells) in response to interleukin-1α. Simvastatin decreased …

[PDF][PDF] IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin

S Malicki, M Winiarski, M Matlok, W Kostarczyk… - J Physiol …, 2009 - jpp.krakow.pl
… of simvastatin decreased generation of both IL-6 and IL-8. The differences in response of
serum levels of IL-6 and IL-8 after tumor removal and treatment with simvastatin … of interleukin 8

Simvastatin reduces serum level of vascular endothelial growth factor in hypercholesterolemic patients

AG Giurgea, C Margeta, T Maca… - Journal of …, 2006 - journals.lww.com
… routinely simvastatin oral treatment (20 mg/d, n = 52; 40 mg/d, n = 55). Simvastatin was …
from all patients on the first day, after 6 weeks and after 6 months of simvastatin treatment. …

Simvastatin stimulates macrophage interleukin-1β secretion through an isoprenylation-dependent mechanism

MW Lindholm, J Nilsson - Vascular Pharmacology, 2007 - Elsevier
… as interleukin-1β (IL-1β). The aim of the present study was to determine if simvastatin affected
lipid … ) and whether simvastatin had a direct effect on cytokine secretion from macrophages. …

Effects of simvastatin gels on murine calvarial bone

MR Thylin, JC McConnell, MJ Schmid… - Journal of …, 2002 - Wiley Online Library
gel at room temperature. Pilot studies showed that 2.2 mg of simvastatin per 50 µl methylcellulose
gel … Fifty µl of the simvastatin gel or gel alone were then injected subcutaneously over …

A clinical, radiological and IL-6 evaluation of subgingivally delivered simvastatin in the treatment of chronic periodontitis

A Rath, J Mahenra, L Thomas… - … Journal of Drug …, 2012 - search.proquest.com
… placement of simvastatin in methylcellulose gel can augment … simvastatin was used in
gel form with carboxymethylcellulose as the vehicle. Researchers have found out that the gels

Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by …

I Inoue, S Goto, K Mizotani, T Awata, T Mastunaga… - Life sciences, 2000 - Elsevier
… of simvastatin. Pravastatin, fluvastatin, and cerivastatin was dissolved in 0.15 M NaCl. Simvastatin
… Pravastatin, simvastatin, and fluvastatin were generous gifts from Novartis Co. (Tokyo, …

Pravastatin suppresses the interleukin8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen …

M Takata, M Urakaze, R Temaru… - British journal of …, 2001 - Wiley Online Library
… Our results suggest that pravastatin inhibits IL‐8 synthesis by blocking the ras‐MAP (p44/42)
kinase pathway rather than nuclear factor‐κB. Pravastatin may prevent atherosclerosis not …