… Here, we show that sirtuin-6 (SIRT6), a member of the sirtuin family of nicotinamide adenine
… the DNA binding activity and transcriptional activity of nuclear factor κB (NF-κB). Importantly, …

… While this review focuses on SIRT6, the nuclear sirtuin that is the subject of transformative …
genomes typically encode for multiple sirtuin family members. Seven sirtuin (Sir2) homologs, …

… Sirtuin 6 (SIRT6), a member of the sirtuin family, has been … growth factor‐β1 (TGF‐β1) is one
of the main factors that can … Mechanistically, SIRT6 decreases phosphorylation and nuclear …

… Nuclear sirtuins (SIRT 1, 2, 6 and 7) in particular may play an … In the present review, we
assessed the roles of nuclear sirtuins … of chronic inflammation, nuclear sirtuins represent potential …

… In another study, SIRT6 upregulation was revealed to contribute to the upregulation of
nuclear factor erythroid 2-related factor 2 (NRF2) and enhanced the release of antioxidants in …

… sirtuins (SIRT1–SIRT7) with different biological functions and subcellular localizations [14],
[15], [16], [17], [18]. Recently, sirtuins … SIRT6, a nuclear sirtuin, has been recently implicated in …

… Based on the positive effect of Sirtuin 6 on Nrf2, we aim to … vivo have revealed that nuclear
factor erythroid 2-related factor 2 (Nrf2… Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD(+)-…

BACKGROUND AND PURPOSE Sirtuin 6 (SIRT6) is involved in regulation of glucose and
fat metabolism. However, its possible contribution to cardiac dysfunction remains to be …

… The protective mechanism of SIRT6 over-expression includes the activation of pAMPKα
pathway, the increased protein level of B-cell lymphoma 2 (Bcl2), the inhibition of nuclear factor …

… a number of transcription factors, including the sirtuin (SIRT) family and nuclear factor κB (NF-…
The sirtuin family consists of seven enzymes (SIRT1–SIRT7) that share a conserved core …