… Specifically, SIRT6 directly interacts with the nuclear factor-κB (NF-κB) RelA subunit or c-…
gene expression [2], [4], [5], [6]. In the brain, SIRT6 has emerged as a key histone deacetylase …

… Sirtuin 6 (Sirt6) is known to exert an anti-inflammatory function, but its role in macrophages …
the activation of nuclear factor-κB (NF-κB) and endogenous production of interleukin-6, which …

… Here, using mouse models and biochemical assays, we show that sirtuin 6 (SIRT6)
deficiency plays a major role in aging-associated transformation of fibroblasts to myofibroblasts, …

… Cytosolic and nuclear extracts were prepared and nuclear protein extracts were analyzed …
PCNA was used as a nuclear loading control, and β-actin was used as an internal control for …

… In mammals, sirtuins have shown to undergo nuclear-cytoplasmic shuttling, where their
functions within the cell are suggested to change depending on each tissue and cell type.3 For …

… Moreover, sirtuin 6 is … sirtuin 6 labeling index without significant differences between the
motor and somatosensory cortex. Our findings contribute to further understanding the sirtuin 6 …

… SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases … nuclear PKM2 (pyruvate
kinase M2) at the lysine 433 residue. PKM2 is a glycolytic enzyme with nonmetabolic nuclear …

… 6 mM D-ala by immunoblotting under non-reducing conditions. Based on our findings in
cytoplasmic and nuclear fractions, we expected that nuclear generated H 2 O 2 would oxidize …

… Figure 1Sirtuin 6 (SIRT6) cellular functions and their impact on organismal biology and …
factors such as nuclear factor κB (NF-κB), c-JUN, Foxo3, MYC, and hypoxia inducible factor 1α (…

… target histone and nonhistone proteins (6). They were initially … Seven sirtuins have been
identified in mammals, with sirtuin 1 … the other 6 sirtuins have been less extensively investigated. …