… sirtuin 1 (SIRT1). SIRT1 belongs to class III of NAD-dependent histone deacetylatase family
which is generally called sirtuin… inhibition of transcription factors, such as nuclear factor κ-light…

… as a transcriptional coactivator of nuclear factor-κB 16 , whereas … through regulation of nuclear
factor-κB transcriptional activity 16 . … The effect of nuclear sirtuins on TNF expression was …

… Sirtuin 6 (SIRT6), a member of the evolutionarily conserved sirtuin family of NAD + -dependent
protein deacetylases, plays an important role in lifespan regulation [3, 4]. It participates in …

… SIRTs occur in various cellular compartments; SIRT1, 2, 6, 7 are nuclear proteins, but SIRT2
… This affects their enzymatic activity in binding substrates [6]. All sirtuins have a catalytic …

… This study demonstrated that myeloid sirtuin 6 is essential in … rheumatoid arthritis in
myeloid-specific sirtuin 6 knockout mice. … transfer arthritis in mice via nuclear factor-κB activation. …

… However, not all sirtuin family members are found in the same place. SIRT1 and SIRT2 are
… increased the nuclear levels of the Ca 2+ -dependent transcription factor, nuclear factor of …

… sirtuins function as longevity assurance factors; but they may have therapeutic potential for
age-associated diseases (1). Seven mammalian sirtuins … -associated nuclear protein affecting …

… the nuclear PKM2 at K433 residue resulting in the nuclear … Moreover, reduced SIRT6 levels
is linked to increased nuclear … however it promotes the nuclear accumulation and protein …

… Mechanistically, a Sirt6 deficiency activates nuclear factor-κB (NF-κB), produces IL-6, and
activates the signal transducer and activator of transcription 3 (STAT3), which ultimately …

… sirtuins decreased the production of tumour necrosis factor-alpha (TNF-α) interleukin 6 (IL-6…
The reduction of cytokine production was associated with decreased nuclear factor kappa B (…