… 1, panels b, e), and merged (panels c and f) images indicated the prevalent nuclear … Our
results are in line with a pro-apoptotic role of Sirtuin 6 as reported in cerebellar granule cells …

… One mechanism is the oxidative stress response, which is controlled by nuclear factor
erythroid 2-related factor 2 (Nrf2), and its regulation of metabolism and innate immunity; this …

… The deacetylase sirtuin 6 (sirt6) was recently implicated in kidney injury. However, it
remains elusive whether and how sirt6 contributes to the regulation of kidney fibrosis. Here, we …

… Here, we review the role of nuclear sirtuins in immune cells and … nuclear sirtuins in the
aging of the immune system, so our knowledge of the importance and specific roles of sirtuins in …

… six other sirtuins are now emerging. Best known is the involvement of sirtuins in helping
cells adapt energy output to match energy requirements. SIRT1 and some of the other sirtuins …

… Endothelial cells express all sirtuin types [9]. Among the seven known sirtuins, sirtuin 1 (SIRT1)
is the most extensively analyzed sirtuin in endothelial cells and is known to be an …

… The majority of research characterising the functional targets of sirtuins has focused on
nuclear SIRT1; however, the other family members are becoming more widely studied. …

… Previously, we reported that the nuclear sirtuin, SIRT6, blocks expression of myostatin, a
negative regulator of muscle growth, through modulation of the NF-κB signalling. This study was …

… The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty-acylation, and mono-…
the nuclear factor Nrf2 expression, consequently inhibits the release of TNF-α and IL-6, and …

… Sirtuin 6 (SIRT6), a member of the Sirtuin family, acts as nicotinamide adenine dinucleotide
(… We found that nuclear accumulation of phosphorylated ERK1/2 was significantly reduced in …