… Understandably, skeletal muscle itself has been the major … , from the cortex down to the
neuromuscular junction (NMJ). It is … to muscle mass, ie a loss of specific or intrinsic whole muscle …

… To further examine whether mitochondria function in skeletal muscle fibers is impaired
without CHCHD10, we checked the ATP levels in Ad-Ctrl and Ad-Cre infected CHCHD10 f/f …

… junction instability/denervation. Collectively, our data suggests that with aging, impaired …
to defects in muscle fiber remodeling and functional recovery of muscle mass and strength. …

… (G) Western blot for LC3 and p62 on the isolated mitochondrial fraction shows an impaired
mitophagic flux in Raptor ko muscles. GRP-75 was used for normalization of mitochondrial …

… This suggests that at least in female mice, denervation events in ageing must primarily occur
as a function of changes within the muscle (eg impaired neuromuscular junction signalling, …

… neural influence on age-related impairments of skeletal muscle, including a role in excitation…
on the neuromuscular junction. A better understanding of nerve–muscle interactions will …

… size, and motor axons and nerve terminals become impaired in their capacity to … and
skeletal muscle. However, irrespective of the cause, the abnormalities at neuromuscular junctions …

… To further examine the extent to which aged skeletal muscles are denervated we performed
genome-wide RNA-seq analysis on synaptic (Syn) and extra-synaptic (ExS) regions of adult (…

… Here, we show that specific inhibition of autophagy in skeletal muscle leads to abnormalities
in motor neuron synapses that ultimately lead to denervation whereas accumulation of …

… whether AHR signalling is elevated in skeletal muscle of smokers and test the hypothesis …
, induces skeletal muscle atrophy, mitochondrial dysfunction, and neuromuscular junction …