… resolution the repair of cyclobutane pyrimidine dimers along the p53 gene … skin cancer,
suggesting that repair efficiency may strongly contribute to the mutation spectrum in a cancer…

… An enzyme which specifically repairs cyclobutane pyrimidine dimers in DNA, T4 endonuclease
V… cyclobutane pyrimidine dimers in DNA are a direct cause of cancer in mammalian skin. …

… pyrimidines, ie cyclobutane pyrimidine dimers (CPD)?, and the less frequent (1530% of CPD
levels) pyrimidine (6-4… In nonmelanoma skin cancer, mutations in the p53 tumor suppressor …

… More than 500,000 new cases of skin cancer are diagnosed … is a principal factor in the
development of skin cancer (1, 2). … of pyrimidine dimers at p53 mutation hotspots in skin cancer. …

… Is it possible that the cancer-free subjects that exhibited low or no repair of UV-induced
pyrimidine dimers may develop skin cancer in the future? Both a prospective study of skin cancer …

… pyrimidine dimers (CPDs) are predominant. Although these lesions are efficiently repaired in
the skin, this … induction and skin cancer). The relationships between the presence of CPD in …

… damage that results in skin cancer resembles that for dimer induction in skin, our results, …
would increase the incidence of nonmelanoma skin cancers among white males in Seattle, …

… gels to detect formation of dimers in the skin of neonatal mice exposed to FS-40 sun lamps.
Our results indicate that pyrimidine dimers are formed in human skin upon exposure to FS-20 …

… Abstract-Cyclobutyl pyrimidine dimers … pyrimidine dimer per million bases in about SO ng
of non-radioactive DNA, and have used this method to quantitate dimer yields in human skin …

… event in the process leading to skin cancer. In this study, … of cyclobutane pyrimidine dimers
are formed in human skin in … a very high risk for developing skin cancer. In addition, a slower …