… To study the relation between repair and mutation hotspots, we examined the repair efficien…
human skin cancers (3). The CPD signal at these positions was sufficient to allow repair rates …

… excision repair pathway, which is defective in rare genetic skin … A major role in inducing
sunlight-dependent skin cancer … ) and in settings where repair of CPDs is relatively slow. …

… delayed repair (heterochromatin) had a higher frequency of cancer-related mutations (112).
This high frequency of mutations in heterochromatin may be attributable to slow repair in …

… mutations in repair-proficient and repair-deficient skin cancers, … of repair affect UV mutagenesis
in human skin cancers. … generally required for repair of the NTS and that slower repair of …

… Two subpathways of repair have been demonstrated: the slow global genome … We must
point out that because XP patients, due to their repair deficiency, develop numerous skin cancers…

… skin cancer by damaging the DNA comes from a rare genetic disease, xeroderma pigmentosum,
which is characterized by defects in the ability of cells to repair … 10 times slower in both …

… Moreover, we have shown that the age-associated slowing of removal of UVinduced DNA
… incidence of skin cancer among the elderly. DNA REPAIR CAPACITY IS INDUCIBLE …

… repair rate, we find that mice exposed to UV radiation (UVR) at 4:00 AM display a decreased
latency and about a fivefold increased multiplicity of skin cancer … repair is predictably slower …

… effects of nucleosomes on repair inhibition and UV damage formation, and their potential
contributions to somatic mutations in skin cancer. A) NER occurs more slowly near the central …

… Results We found that subsets of these 10 MMR protein measures were increased in
nonmelanoma skin cancer (NMSC) compared with normal epidermal samples; this was particularly …