… Oxidative stress in keratinocytes may be generated by xenobiotics, eg, arsenic, which is an
inducer of carcinogenesis in HaCaT cell line. Increased ROS generation (mainly hydrogen …

… with a functional aryl hydrocarbon receptors (AhR) and cytochrome P1-450 activity,
whereas it directly responded to electrophilic inducers such as trans-4-phenyl-3-buten-2-one, …

… Based on the known activity of electrophiles containing an α,β-unsaturated carbonyl
pharmacophore (‘Michael acceptors’) as potent inducers of the Nrf2 target gene NQO1, we …

… In an attempt to explore the Nrf2-based cytoprotective potential of … for skin cell photoprotection
against solar UV radiation. To this end, potency of transcriptional activation of Nrf2 in Hs27 …

… Nrf2 inducers. Besides exogenous stressors, there are several endogenous Keap1 modifiers
such as nitric oxide, fumarate, hydrogen peroxide, cyclopentenone prostaglandins and nitro…

… NRF2 to skin pathophysiology and we discuss some recent modulators of NRF2 activity that
have shown a therapeutic efficacy in skin … A list of the NRF2 inducers discussed above and …

… Figure 1: The mechanism of activation of the Nrf2-Keap1-ARE pathway The panels show
the continuous degradation of Nrf2 in absence of inducer (left panel) and the classical …

… in the KeratinoSens™ cell line at the mRNA level and discriminate Nrf2-dependent and Nrf2-…
luciferase signal in KeratinoSens™ cells is completely dependent on Nrf2. The same holds …

… skin cancer. Normal human keratinocytes (NHK) and melanocytes (NHM) were treated by
chemical inducers of the Nrf2 … that Nrf2 is involved in pathways of the human skin adaptation to …

… However, the numerous and partly contradictory effects on skin cells depending on dose …
The limitations of the presented studies are twofold: First, we showed that the Nrf2 inducer LicA …