… Susceptibility to SLE has a … in SLE is the presence of autoreactive B cells, which predominantly
target nuclear antigens. In addition to evidence of aberrant B and T cell behaviour, lupus …

… immune cell players with novel roles in disease pathogenesis. Despite these major advances,
there is a paucity of specific targeted therapies for SLE. In this review we focus on cellular …

… cells from patients with SLE. 32 These effects appear to be unique to patients with SLE,
indicating that lupus T cells … may aggravate SLE by prolonging the survival of autoimmune cells, …

… lupus-prone mice, suggesting that the increased activity of this gene may also be relevant for
disease pathogenesis in patients with SLE … T and B cell hyperreactivity in SLE. In particular, …

… further recognized by autoreactive cells. Here we explore the complexity of SLE pathogenesis
through five core issues, ie genetic predisposition, B and T cell abnormalities, abnormal …

… lupus erythematosus, the pathogenesis of SLE, the role of B/T cells in SLE, and classification
criteria of SLE. … T cells play a significant role in SLE pathogenesis, driving inflammation by …

… role of myeloid cells in the pathogenesis of SLE, confirmed roles for T and B cells in SLE,
promoted clinical trials based on the prominent interferon signature found in SLE patients, and …

… SLE according to the cell types and molecular pathways in which they are expressed, to gain
insight into the key pathogenic contributors that lead to lupus … from apoptotic cells. While the …

… cells from SLE that may be fundamental to the disease. This review will examine the role of
… cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells …

… lupus erythematosus (SLE) … SLE and reshaped current pathogenic models. Here, we review
recent findings that deal with (i) genes associated with disease expression; (ii) immune cell …