… in cell differentiation, this review summarizes the present evidence for the involvement of
STAT pathways in the pathogenesis of SLE … responses in SLE CD4+ T and B cell subsets and …

… the cycle of autoreactive cells and autoantibody production are not completely clear. This
review provides an updated overview of type I IFN in SLE pathogenesis, clinical manifestations…

… Our understanding of the pathogenesis of systemic lupus erythematosus (SLE) … cells are at
the apex of the cascade of pathogenetic mechanisms in systemic lupus erythematosus (SLE). …

… pathogenesis of SLE, we still lack sufficient knowledge about the disease for developing
effective therapies for lupus … kidneys of SLE patients and in the mesangial cells of lupus mice, …

… Although there is evidence for Th2 cytokines promoting some elements of chronic nephritis,
the overwhelming contribution of T cells in systemic lupus erythematosus appears to be Th1-…

… , lupus mice do not receive medication and the congenital strain limits phenotypic differences.
We will focus on two lupus models in this review, in which Treg-cell … to SLE pathogenesis. …

… T cells and B cells from patients with SLE; eight miRNAs exhibited altered expression only
in T cells from patients with SLE whereas four miRNAs had altered expression in B cells only. …

… Integrated hypothesis for the pathogenesis of SLE and lupus nephritis. (1) Apoptotic blebs
and chromatin are ingested by immature myeloid dendritic cells (mDC), which, thereby, (2) are …

… to be involved in SLE pathogenesis as autoreactive B and/or T cells might survive death …
involving B or T cell tolerance are directly involved in the pathogenesis of SLE. Autoimmune …

… lupus erythematosus in the NZM2410 murine model maps to Slel, Sle2, Sle3, and the HZ loci.
To unravel how these loci contribute to the pathogenesis of lupus, … their B cells. They have …