… At sleep onset, calcium transient activity of RIS increases and leads to the release of … induce
quiescence. Thus, we show that sleep can be induced systemically by the single RIS neuron …

… of sleep to actively induce this state by directly inhibiting wakefulness. These sleep-inducing
neurons … should depolarize prior to sleep-active neurons, before sleep induction, when the …

… disturbed sleep control gene expression. Central to the induction of sleep are sleep-active
neurons… Sleep and sleep-active neurons are highly conserved. In Caenorhabditis elegans, the …

… This work motivated mechanistic studies of neuronal sleep … to sleep induction are sleep‐active
sleep‐promoting neurons … required for sleep induction, ie, sleep‐active neurons and their …

… Sleep has been conserved throughout evolution; however, the … neuronal mechanisms of
sleep are largely unknown. The hypothalamic hypocretin/orexin (Hcrt) neurons regulate sleep\…

… Sleep-active neurons are under the control of homeostatic mechanisms that determine
sleep … that translate sleep need into the depolarization of sleep-active neurons. During many …

… Ablation of this gene results in a >30% loss specifically of Hcrt neurons, without a general …
of Hcrt neuron gene expression and suggest that Lhx9 may be important for specification or …

… The genetic background of an individual may affect this sleep… the expression of genes
following sleep loss. We tested the … circadian, sleep and neuronal plasticity genes following sleep …

… activation by REM-sleep deprivation, projection to pontine areas controlling REM sleep, and
… ), suggesting that this group of midbrain GABAergic neurons is involved in sleep regulation. …

… The promise of this approach is highlighted by the recent demonstration that narcoleptic-like
sleep induced by the lesion of Hcrt neurons in rats is diminished by the transplantation of …