… fly Drosophila melanogaster, the neuropeptide leucokinin is required for the modulation of
starvation-dependent changes in sleep. … In mammals, the activity of some sleep- and wake-…

… (B) Total daily sleep, total daily activity, sleep bouts, and waking activity index for each
genotype denoted at the bottom of each panel; TKO x w 1118 (n = 16), TKO x dilp2 KO (n = 16), …

… not differentiate between waking or sleep in flies. When responsiveness is analyzed only
for … We have not completely excluded the possibility that a fast-acting neuropeptide or …

… Drosophila and other insects reinforces the model of the brain clock as a network of coupled
circadian oscillators and has identified neuropeptides … locomotor patterns, sleep timing, and …

… (PDF) and small neuropeptide F (sNPF), which play important roles in sleep/rhythms and …
Future studies should build off of this work to determine if sNPF targets and inhibits wake-…

… in understanding sleep and arousal. Here, we have systematically studied all 13 ACh receptors
(AChRs) in Drosophila to understand mechanisms underlying ACh function in sleep and …

… As for sNPF, we [53] and another group [54] demonstrated that sNPF regulates Drosophila
sleep. We showed that it does so through a cAMP-PKA-CREB pathway. Moreover, sNPF and …

… intensity and duration are believed to be controlled by homeostatic processes, where the
duration of wakefulness influences the drive to sleep. While there is a close link between the …

… the helicon cells (via release of the sleep-promoting neuropeptide, allatostatin); inhibition
of … of a particular neuron is actually waking an animal from sleep or whether it is simply …

… the involvement of the Orcokinin neuropeptides (OKs) in the regulation of different Drosophila
behaviors: ecdysis, locomotor activity and its circadian control, and sleep. We also studied …