… Smad3 acetylation reduces the phosphorylation of Smad 3 and its nuclear accumulation. We
can thus speculate that preventing Smad3 … Altogether, Smad3 acetylation in the nucleus is …

… Despite the importance miRNAs play in regulating myogenesis in vitro, surprisingly little
impact has been observed on skeletal muscle phenotype following the deletion of the majority of …

… smooth muscle cells of the media change their phenotype to … acetyl transferases, p300 and
P300/CBP-associated protein, are involved in altered transcription factor binding to the Smad …

… Mdx mice present an overall milder phenotype than DMD patients 66 . This is … Smad3
acetylation but both Smad2 and 3 phosphorylation. In muscle treated with TubA, the acetylation of …

… muscle cell (SMC) differentiation, migration, and maturation during vasculogenesis and in
vascular diseases [1]. Smad … of Smad3 and p300 and induces histone acetylation at the SM22 …

… , which in turn resulted in increased histone acetylation at the binding sites of the transcription
… phenotype (18). Thus we speculated that Smad3 may serve normally to suppress MMP9. …

… increases in H3K9/14 acetylation and H3K4 methylation are … of the TGF-β/Smad signalling
pathway. Smad2 activation and the … of Smad expression as a specific arterial SMC phenotype …

… Effect of TGF-β1 on myofibroblast phenotype, total H3 acetylation, and cell-cycle progression…
inhibitor of canonical signaling intermediate Smad3. Bioenergetic analysis showed reduced …

… Here we show that the TGF-β intracellular effector Smad3, but not Smad2, mediates the …
The Smad3-mediated repression was directed at the E-box sequence motif within muscle gene …

… Consistent up-regulation of Myostatin expression in Smad3-null TA muscle during the
course of muscle regeneration ........................................................... 136 4.4 Discussion ..........................…