… Smad3 acetylation reduces the phosphorylation of Smad 3 and its nuclear accumulation. We
can thus speculate that preventing Smad3 … Altogether, Smad3 acetylation in the nucleus is …

… by controlling Smad3 acetylation. Pharmacological inhibition and genetic depletion of
ERK5 … , a pharmacological inhibitor of MEK5/ERK5, completely recovered survival rate and …

… This study investigated Smad3 acetylation in renal fibrosis. … cells induced Smad3 acetylation
and phosphorylation. … , reversed acetylation but not phosphorylation of Smad3 and inhibited …

… whether the inhibition of TGF-β1-induced EMT and hyper acetylation of Smad2 and … and
Smad3 acetylation by p300/CBP, we examined the in vivo acetylation of Smad2 and Smad3 by …

… In this study, we carried out a detailed analysis of acetylation of Smad proteins by p300. We
show that Smad2, but not Smad3, can be acetylated in a p300-dependent manner and that …

… the HDAC6 inhibitor suppressed TGF-β-induced acetylated histone H4 or phospho-Smad2/3
to Smad3 … Pharmacological inhibition or genetic ablation of HDAC6 blocked kidney fibrosis. …

… We report here that Akt, activated downstream from ERK 1/2, was required for TGF-β1-induced
ZEBRA expression and enabled Smad3, a mediator of TGF-β1 signaling, to be acetylated …

… Smad3 was degraded by PROTAC with whole-cell lysate of ACHN but not 786-0. Degradation,
but not ubiquitination, of Smad3 was inhibited by proteasome inhibitor … were inhibited by …

… Thus, genetic or pharmacologic inhibition of TRIB3 expression may benefit cancer patients.
In this study, we found that metformin attenuates melanoma growth and metastasis in …

… acetylation and thereby remodeling the chromatin template (12, 13). The C-terminal domains
of Smad3 or … to associate with Smad3 on TGF-β receptor activation and to enhance TGF-β/…