… In this study, we have shown the acetylation of Smad3 by p300/CBP in response to TGF-β. …
for the regulation of Smad3 by TGF-β. TGF-β binds to TGF-β receptors and phosphorylates …

… In this study, we carried out a detailed analysis of acetylation of Smad proteins by p300. We
show that Smad2, but not Smad3, can be acetylated in a p300-dependent manner and that …

… Smad3 are acetylated in response to TGF-β1 signaling, and the acetylated Smad2 and Smad3
… that EGCG blocked acetylation of Smad2 and Smad3 by p300/CBP in the nucleus during …

… Several pieces of evidence from our study suggest that Smad3 acetylation is also an
important signaling pathway causing ECM production: (1) 5/6 nephrectomy in rodents or …

… of TGFβ target genes. In the current study, we demonstrate that both Smad2 and Smad3 are
acetylated by the coactivators p300 and CBP in a TGFβ-dependent manner. Smad2 is also …

… HDAC6 being strictly cytoplasmic, Smad3 … Smad3 acetylation reduces the phosphorylation
of Smad 3 and its nuclear accumulation. We can thus speculate that preventing Smad3 …

… well as increased acetylation of NF-κB. Thus, upon TGF-β activation, phosphorylated Smad3
can be … We conclude that TGF-β-Smad3 signaling is very finely regulated during early lung …

… Notably, ERK5 regulates TGF-β1–induced fibrogenic signaling via Smad3 acetylation. …
a critical role in TGF-β1–induced pulmonary fibrosis via enhancing Smad3 acetylation. This …

… to a large family of TGF-β ligands including TGF-βs, activins … that Smad signaling is fine-tuned
to regulate diverse TGF-β-… ubiquitination, SUMOylation and acetylation, as discussed in …

… In agreement with this finding, histone acetylation is induced by Smad3 and p300, and
abolished by the addition of c-Ski. Expression of c-Ski is regulated by various factors, including …