Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells
Y Ding, X Chen, C Liu, W Ge, Q Wang, X Hao… - Journal of hematology & …, 2021 - Springer
… cells, are susceptible to ferroptosis [4, 5]. Small molecule ferroptosis inducers had a strong
… tmozolomide, cisplatin, doxorubicin with ferroptosis inducer erastin resulted in a remarkable …
… tmozolomide, cisplatin, doxorubicin with ferroptosis inducer erastin resulted in a remarkable …
Using small molecules to dissect non‐apoptotic programmed cell death: necroptosis, ferroptosis, and pyroptosis
T Dong, D Liao, X Liu, X Lei - Chembiochem, 2015 - Wiley Online Library
… pathological conditions, the detailed molecular mechanisms underlying them are … small
molecules to dissect three forms of non-apoptotic programmed cell death: necroptosis, ferroptosis…
molecules to dissect three forms of non-apoptotic programmed cell death: necroptosis, ferroptosis…
Targeting regulated cell death with pharmacological small molecules: An update on autophagy-dependent cell death, ferroptosis, and necroptosis in cancer …
J Wu, J Ye, Q Xie, B Liu, M Liu - Journal of Medicinal Chemistry, 2022 - ACS Publications
… have an advantage to bypass the apoptosis-resistance machinery. Thus, … molecular insights
into ADCD, ferroptosis, and necroptosis and summarize the corresponding small molecules …
into ADCD, ferroptosis, and necroptosis and summarize the corresponding small molecules …
Ferroptosis-related small-molecule compounds in cancer therapy: strategies and applications
L Yin, P Liu, Y Jin, Z Ning, Y Yang, H Gao - European Journal of Medicinal …, 2022 - Elsevier
… ferroptosis and tumor-related signaling pathways, as well as comprehensively summarizing
the small-molecule … Early forms of RCD include apoptosis, autophagy and necrosis [4]. In …
the small-molecule … Early forms of RCD include apoptosis, autophagy and necrosis [4]. In …
Recent advances in small-molecule fluorescent probes for studying ferroptosis
YL Qi, HR Wang, LL Chen, YT Duan… - Chemical Society …, 2022 - pubs.rsc.org
… Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death driven by
excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality of …
excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality of …
Mechanisms of ferroptosis
JY Cao, SJ Dixon - Cellular and Molecular Life Sciences, 2016 - Springer
… Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules
or … Conversely, a number of small molecule inhibitors of ferroptosis have been identified, …
or … Conversely, a number of small molecule inhibitors of ferroptosis have been identified, …
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
… Ferroptosis, an alternative cell death program to apoptosis, promises access to anticancer
strategies that selectively kill malignant cells and are effective against aggressive, drug-…
strategies that selectively kill malignant cells and are effective against aggressive, drug-…
Targeting programmed cell death using small‐molecule compounds to improve potential cancer therapy
B Ke, M Tian, J Li, B Liu, G He - Medicinal research reviews, 2016 - Wiley Online Library
… Small-molecule compounds that may target parthanatos and ferroptosis in cancer. (A) Some
… Distinguished from frequently used apoptotic agents, small molecules of MC may induce …
… Distinguished from frequently used apoptotic agents, small molecules of MC may induce …
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
H Yu, P Guo, X Xie, Y Wang… - … of cellular and molecular …, 2017 - Wiley Online Library
… underlying ferroptosis induction differs from that of apoptosis and … ferroptosis-inducing small
molecules exhibit a remarkable selectivity towards cell strains 33. Moreover, the ferroptosis …
molecules exhibit a remarkable selectivity towards cell strains 33. Moreover, the ferroptosis …
[HTML][HTML] The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers
CZ Feng, NZ Li, XB Hu, YY Xie, QH Huang… - Genes & …, 2023 - ncbi.nlm.nih.gov
… We found that the BT-549 cells similarly underwent ferroptosis rather than apoptosis upon
EC330/EC359 treatment, because they were largely rescued by DFO and Fer-1 (Fig. S4). …
EC330/EC359 treatment, because they were largely rescued by DFO and Fer-1 (Fig. S4). …
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