… DNA demethylation inhibitors has been lagging. This review will discuss DNA methylation
and demethylation machineries, and their therapeutic potentials as targets for small molecule …

… of DNA methylation during the maintenance of DNA methylation; it must not be excluded
that these compounds may trigger active demethylation mechanisms that are not yet identified. …

… effective in scanning small molecules for potential interactions … new insights into the DNA
methylation process. NSC401077, in … In addition, our data showed a substantial demethylating …

… We review here knowledge about DNA methylation to provide … Ideally, demethylation of
CmG islands and of repeat … are easily demethylated, but CmG islands are demethylated only …

… For a long time, histone methylation was considered as an irreversible modification. But
while the existence of an actual arginine demethylase still remains to be proven, two classes of …

… , a wave of global de novo methylation re-establishes the DNA methylation patterns that will
be maintained, in large part, in somatic tissues. Genome-wide demethylation also occurs in …

… of DNA methylation are highly dynamic between cell types. Here, we discuss the importance
of DNA methylation for genome regulation and the mechanisms that remodel the DNA …

… and maintenance of defined DNA methylation patterns that … demethylating activities for a
few other small molecules. For … anesthetic procaine induce demethylation at high micromolar …

… Any clinical effect of these weak “demethylating” drugs may require prolonged exposure
to … of small molecules targeting DNA methyltransferases (20). These small molecules have …

… maintenance of the methylation pattern, both generation of DNA methylation and its removal
… of ongoing DNA methylation and demethylation shapes the final epigenetic methylation …