… regulatory sequences or encode additional small RNAs of an abundance too low to be
detected in our experiments. No other h-4 products besides lin-4L and lin-4s were consistently …

… between lin-4 and the lin-14 3′ UTR was essential for the ability of lin-4 to control LIN-14 …
Through an analogous mechanism, lin-4 also negatively regulates the translation of lin-28 , …

… the ability of lin-4 to directly repress lin-14 expression. Both … discovery efforts aiming for small
RNAs discovery, particularly … provide important insights into the core of small RNA biology. …

… Recently, two other groups of small RNAs have received much attention: small … . The lin-4
regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 …

… Like lin-14, let-7 encoded a small RNA that negatively regulated the expression of a second
gene (lin-41) through conserved elements in the 3′ UTR of that gene. Unlike lin-14, let-7 …

… that the temporal regulation of lin-14 translation is controlled by lin-4 RNA via antisense
RNA–RNA interaction involving the small RNA lin-4 and the 3′UTR of lin-14. Seven years later, …

… loops both in the lin-4 RNA strand and in the lin-14 mRNA strand, so … small RNAs has been,
we may still only be viewing the tip of the iceberg. We have most of the data for small RNAs …

… Depletion of eIF6 abolishes miRNA-mediated gene silencing in human cells and the lin-4
mediated translation repression of lin-14 and lin-28 in C. elegans. The involvement of eIF6 in …

… sites of sequence complementarity in the lin-14 3′-untranslated … lin-14 messenger RNA
(mRNA) into a protein was inhibited by the binding of the small lin-4 RNA molecule to the lin-14 …

… Small RNAs and evolutionarily conserved RNA-mediated silencing pathways have … lin-4
regulator RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 …