… in the reciprocal control of appetite for sodium and water 50 . … the mouse SFO and the sodium
channel Na x were present in … in water and sodium homeostasis, vasopressin release and …

… Lithium enters the collecting duct principal cells predominantly via epithelial sodium
channels (ENaC). Excess lithium reduces sodium reabsorption. Lithium inhibits AVP-stimulated …

… Please note that Na reabsorption, through the epithelial sodium channel, is not represented.
AVP is bound to the V 2 receptor (a G-protein–linked receptor) on the basolateral membrane…

… be sodium load. Particularly with NDI, solute concentration is an important contributor to urine
output, which is why relative salt restriction (a diet low in sodium … from decreased sodium …

… /sodium that stimulates thirst and a compensatory increase in water intake (polydipsia) which
prevents further decline in body water. As a result, plasma osmolarity/sodium … /sodium that …

… sodium channels (ENaCs), which have a high permeability for lithium. Consequently,
treatment with ENaC blockers, such as amiloride, can increase urine osmolality and ameliorate …

… on central diabetes insipidus and describe the prevalence, the clinical manifestations, the
etiology as well as the differential diagnosis and management of central diabetes insipidus in …

… diabetes insipidus; amiloride appears to prevent its occurrence in some clinical cases. Amiloride
blocks the epithelial sodium channel (… lithium-induced diabetes insipidus, thus providing …

… Lithium enters the renal tubular cells through amiloride-sensitive sodium channels. Its
mechanisms of action within the cell are not clear. It may modulate the function of pertussis toxin …

… serum sodium of <140 meq/L and a dilute urine with urine osmolality of <100 mOsm/Kg on
the one hand and diabetes insipidus on the other hand. It is associated with a serum sodium …