… the vasopressin-sensitive water channel gene (aquaporin 2 [… ” diabetes insipidus:
Neurohypophyseal diabetes insipidus, X-… These cells express the epithelial sodium channel …

… water channel aquaporin-2 (AQP2) ( 4 ). The CNT and CD are also the site of amiloride-sensitive
sodium reabsorption via the epithelial sodium channel (ENaC) ( 5 ). Sodium transport …

… Diabetes insipidus (DI) is characterized by hypotonic polyuria greater than 3 liters/24 hours
… In severe forms of DI, urine osmolality remains below 250 mOsmol/kg and serum sodium …

… water which reduces plasma osmolality and sodium by a corresponding 1–2%, thus
suppressing AVP secretion and inducing polyuria Citation[8]. Sodium levels usually remain in the …

In nephrogenic diabetes insipidus, the kidney is unable to concentrate urine despite normal
or elevated concentrations of the antidiuretic hormone arginine vasopressin (AVP). In …

… such as diabetes insipidus (DI) or nephrogenic syndrome of inappropriate diuresis (NSIAD).
The DI is characterized by excessive production of hyposmotic urine (“insipidus” means …

… of body sodium and … effect in diabetes insipidus, HCTZ may directly or indirectly act in the
distal nephron segments and collecting duct to affect expression of water channels and sodium …

… sodium influx [33]. Urine subsequently enters the thick ascending limb (TAL), which is
impermeable for water, but actively removes sodium … ) and the entry of sodium chloride (into the …

… diabetes insipidus, the inability to respond appropriately to vasopressin. The goal of treatment
in both forms of diabetes insipidus is to … Amiloride blocks epithelial sodium channels in the …

… sodium levels >145 mEq/L (accepted normal range is 135-145 mEq/L) points towards central
or nephrogenic DI while a low sodium … /kg, decreased urinary sodium level, urinary specific …