… nature of macrophage polarization (17, 18); here, we provide a brief overview … macrophage
phenotype for the context of solid tumor therapies. “Classically activated” (M1) macrophages …

… tumor invasion, and mediate immunosuppression. Because macrophages can infiltrate solid
tumor … cellular components in the tumor microenvironment (including tumor cells, immune …

… , and designs of CAR-engineered macrophages (CAR-Ms) and neutrophils (CAR-Ns), their
… research directions for the broader applications of CAR-Ms and CAR-Ns in solid tumors. …

… of solid tumors. In this review, we explained the macrophage cell and their roles in TME,
correlation between the CAR structure and these cells, compared CAR M cells to other …

… the development of a strategy for TAM depletion in mouse solid tumor models using chimeric
antigen receptor (CAR) T cells targeting the macrophage marker F4/80 (F4.CAR-T). F4.…

… CAR-M therapy has shown unique and impressive antitumor effects in … for solid tumors.
However, the polarization state of macrophages can affect the antitumor effect of CAR-M. We …

… in macrophages may widen the spectrum of CAR applications for better control of solid tumors
… Given the novel insights into tumor-associated macrophages and new targeting strategies …

… Consequently, there is significant interest in developing CAR macrophages for … with CAR
T/NK therapy, especially in solid tumors. Nevertheless, both CAR NK and CAR macrophages …

… , challenges faced in treating solid tumors, and insights gleaned … solid tumors. We especially
highlight the potential advantages of CAR-macrophage therapy over CAR-T for solid tumors…

… receptor macrophages (CAR-Ms) may provide even greater benefit for patients with solid
tumors. In this review, we discuss how TAMs promote the progression of solid tumors as well as …