… This review focuses on ongoing or completed clinical trials with combination targeted
therapies for solid tumors and highlights the successes and ongoing challenges. Novel strategies …

… solid tumor application of CAR-T therapy (Table 2). In this section, we conclude three approaches
to … CAR-T cells’ infiltration into solid tumors, (2) surmounting tumor immunosuppressive …

… is a rational approach in the treatment of solid tumors. Translation of this approach from …
understanding of tumor radioresistance and the cellular response to ionizing radiation (IR). …

… resistance and the subsequent design of rational therapeutic combinations on a per patient
basis. In … medicine approach to maximize immunotherapeutic benefit for all cancer patients. …

… and showed greater efficacy in patients with solid tumors, while there was no response of …
response in a clinical trial conducted on patients with solid tumors [89]. By contrast, the …

… approaches are attributed to reductionist approaches to research and infinite numbers of
genetic mutations in chaotic molecular environment of solid tumors … future logical approaches to …

… to imatinib mesylate, it is hoped that new approaches to forestalling the development …
variety of solid tumors, including GISTS, will better define the role of this rationally designed, …

… targeted therapies in advanced solid tumors in order to identify … of the efficacy of rational
combination therapies. Selected … select rational combination immunotherapy approaches.13 …

… However, their efficacy in the treatment of solid tumors is still far from expectation due to
tumor-induced immunosuppression, insufficiency of adoptive T cell homing to the tumor, and …

… target for classical small-molecule drug approaches, and crystallographic studies have not
… Consequently, the approaches currently at the most advanced stages of clinical evaluation …