… well prostate … cancer aggressiveness and forestall the introduction of personalized
medicine.3 The aim of this study was to assess somatic heterogeneity of multifocal prostate cancer …

… somatic alterations in localized prostate cancer from the Cancer Genome Atlas (TCGA)
prostate cancer study.Early … Somatic alterations contributing to metastasis of a castration‐resistant …

… Likewise, we found that somatic alterations in BRCA2 were present … somatic BRCA2 loss
of function alterations occur early in tumorigenesis for affected patients. Conversely, alterations …

… Our results indicate that somatic alteration of TET2 occurs at a significant frequency in
mCRPC (Table 2, Fig. 3). The gene encodes a protein belonging to a family of three related …

… Driver Somatic Alterations To assess the functional relevance of these somatic alterations,
we … Because a relevant portion of the somatic alterations identified may constitute passenger …

… altered in the germline of men with metastatic prostate cancer. … and somatic alterations in a
set of primary prostate tumors and … from 944 unique men with prostate cancer. Frequencies of …

… about the role that the common somatic mutations can play in … prostate cancer. We describe
how detailed molecular genetic analyses of the tumor microenvironment of prostate cancer …

… involved in the management of prostate cancer to understand the relevance of … prostate
cancer risk and cancer biology, and acquired (somatic) mutations that occur in prostate cancer …

… most frequent somatic alterations in tumours from men with metastatic prostate cancer.
Molecular tests are now available for detecting some of these germline or somatic alterations and …

… Somatic alterations predisposing to chromosomal rearrangements in PC remain largely
undefined. We show that KIT, KRAS, and TP53 genes have a higher presence among patients …