Highly sensitive DNA sequencing techniques have allowed the discovery of large numbers
of somatic mutations in normal tissues. Some mutations confer a competitive advantage over …

… We review recent evidence for non-genetic mechanisms of progression, explain the … ,
and provide a framework for unifying genetic and non-genetic dynamics in tumor progression. …

… While the underlying molecular mechanisms for gene conversion and somatic hypermutation
are unknown, inferences can be made by the footprints left behind in their target sequences…

… of somatic evolution and cancer as a product of three major orthogonal processes: occurrence
of somatic mutations, evolution of … is a straightforward evolutionary mechanism that should …

… terms to achieve the converse of the genetic assimilation of acquired characteristics. That
is, they might profitably hand over to somatic homeostatic mechanisms the control of some …

… To understand the mechanisms underlying cancer evolution, we need to conduct
systematic analyses on the ageing process. From a clinical point of view, identifying pre-symptomatic …

… on SC clonal dynamics and somatic evolution in general. However, the mechanisms that
translate somatic evolutionary processes into the actual cancer risk need to be addressed. …

… In spite of our understanding of the primary mechanisms that likely gave rise to somatic
recombination (ie RAG transposition), neither the identity of the target of the initial event that gave …

… “somatic evolution” caused by accumulating random mutations. Here, we propose an alternative
model in which the initial genetic … integrates both genetic and nongenetic mechanisms. …

… somatic gene conversion remain largely unknown. In this review, we focus on phylogenetic
aspects of somatic hypermutation of Ig genes … gene conversion be the mechanism of somatic …