… clonally expanded CSF B cells in MS patients demonstrated the preferential usage of the VH
IV family. There were numerous somatic … a high frequency of clonally expanded B cells that …

… Subsequent encounter with antigen in the appropriate cellular environment drives B-cell
clonal proliferation and somatic hypermutation in germinal centers of secondary lymphoid …

… Adaptive immune receptor repertoire sequencing (AIRR-Seq) offers the possibility of identifying
and tracking B cell clonal expansions during adaptive immune responses. Members of a …

… clonal and oligoclonal expansion of these synovial B cells. These clonally expanded B cell
clones are mainly T cell-dependent, postgerminal center (GC) B cells with Ag-driven somatic …

… We provide here evidence that B-cell clones expand and undergo SHMs in situ. However,
the even distribution of nonsilent SHM in high-frequency graft sequences together with the …

… These data indicate that clonal expansion takes place in the human marginal zone… somatic
hypermutation occurs during clonal expansion in the marginal zone. Alternatively, the somatic …

… B cells governs the extent of clonal expansion, we titrated the … selection, proliferation and
somatic hypermutation in the GC, … H 4 for somatic mutations, because this region is targeted for …

… hypermutation are triggered by replication stress in an MMR-deficient background, enabling
clonal expansion of … MSI and hypermutation efficiently lead to clonal expansion of cells with …

… and, owing to the clonal stability of HPF recruitment, the transgenes in these cells may
incorporate multiple somatic mutations during clonal expansion (Fig. 7). This line of thinking has …

… It is on the one hand the dramatic clonal proliferation of GC B cells, and on the other the
genetic changes a B cell encounters within the GC tnicroenvironment, which increase the risk of …