Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
… spatial organization remains challenging. We combine a microarray-based spatial transcriptomics
method that reveals spatial … intersection analysis to primary pancreatic tumors, we find …
method that reveals spatial … intersection analysis to primary pancreatic tumors, we find …
Spatial transcriptomics in pancreatic cancer: advances, prospects and challenges
Y Li, Y Du, R Li, W Zhong, X Zou, L Li, L Xu… - Critical Reviews in …, 2024 - Elsevier
… Pancreatic cancer development is a continuous process, and researchers are attempting to
… spatial transcriptomics (ST) technology, thereby constructing models of pancreatic cancer …
… spatial transcriptomics (ST) technology, thereby constructing models of pancreatic cancer …
Spatial transcriptomics technology in cancer research
… For instance, a functional subgroup was found in mouse pancreatic cancer model in a
hypoxic microenvironment. Furthermore, the hypoxia-induced tumor tissues had less …
hypoxic microenvironment. Furthermore, the hypoxia-induced tumor tissues had less …
Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment
… Spatially-resolved transcriptomics revealed an association between malignant cells … Our
refined molecular taxonomy and spatial resolution can help advance precision oncology in …
refined molecular taxonomy and spatial resolution can help advance precision oncology in …
Progress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer
J Zhu, K Zhang, Y Chen, X Ge, J Wu, P Xu… - Journal of Translational …, 2024 - Springer
… The study of RNA analytes using spatial transcriptomics can be performed with different
methods [31]. Overall, spatial transcriptomics methods can be divided into four broad categories […
methods [31]. Overall, spatial transcriptomics methods can be divided into four broad categories […
Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity
… By applying spatially resolved transcriptomics to matched primary and metastatic PDAC …
immunosuppressive spatial ecotypes across anatomical regions. We observed spatial tumor …
immunosuppressive spatial ecotypes across anatomical regions. We observed spatial tumor …
Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma
… , the characterization of their spatial organization within it has been more elusive. The
recently introduced ‘spatial transcriptomics’ method (ST) reveals the spatial pattern of gene …
recently introduced ‘spatial transcriptomics’ method (ST) reveals the spatial pattern of gene …
Single-nucleus RNA-seq and Spatial Transcriptomics of Archival Primary Pancreatic Ductal Adenocarcinoma Uncovers Multi-compartment Intratumoral Heterogeneity …
… spatial transcriptomics. Our results reveal important biological insights that have direct
implications on the treatment of PDAC. We are using our data to deconvolve cell type proportions …
implications on the treatment of PDAC. We are using our data to deconvolve cell type proportions …
… ‐cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid …
T Zhan, Y Zou, Z Han, XR Tian, M Chen… - Clinical and …, 2024 - Wiley Online Library
Aim The main focus of this study is to explore the molecular mechanism of IRF7 regulation
on RPS18 transcription in M1‐type macrophages in pancreatic adenocarcinoma (PAAD) …
on RPS18 transcription in M1‐type macrophages in pancreatic adenocarcinoma (PAAD) …
Spatial Transcriptomics of Intraductal papillary mucinous neoplasms of the Pancreas identifies Nkx6-2 as a driver of gastric differentiation and indolent biological …
M Sans, Y Makino, J Min, KI Rajapakshe… - Cancer discovery, 2023 - AACR
Identification of the molecular features driving IPMN development and differentiation is critical
to prevent cancer progression and enhance risk stratification. We used spatial profiling to …
to prevent cancer progression and enhance risk stratification. We used spatial profiling to …
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