Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

R Moncada, D Barkley, F Wagner, M Chiodin… - Nature …, 2020 - nature.com
spatial organization remains challenging. We combine a microarray-based spatial transcriptomics
method that reveals spatial … intersection analysis to primary pancreatic tumors, we find …

Spatial transcriptomics in pancreatic cancer: advances, prospects and challenges

Y Li, Y Du, R Li, W Zhong, X Zou, L Li, L Xu… - Critical Reviews in …, 2024 - Elsevier
Pancreatic cancer development is a continuous process, and researchers are attempting to
spatial transcriptomics (ST) technology, thereby constructing models of pancreatic cancer

Spatial transcriptomics technology in cancer research

Q Yu, M Jiang, L Wu - Frontiers in Oncology, 2022 - frontiersin.org
… For instance, a functional subgroup was found in mouse pancreatic cancer model in a
hypoxic microenvironment. Furthermore, the hypoxia-induced tumor tissues had less …

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

WL Hwang, KA Jagadeesh, JA Guo, HI Hoffman… - BioRxiv, 2020 - biorxiv.org
Spatially-resolved transcriptomics revealed an association between malignant cells … Our
refined molecular taxonomy and spatial resolution can help advance precision oncology in …

Progress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer

J Zhu, K Zhang, Y Chen, X Ge, J Wu, P Xu… - Journal of Translational …, 2024 - Springer
… The study of RNA analytes using spatial transcriptomics can be performed with different
methods [31]. Overall, spatial transcriptomics methods can be divided into four broad categories […

Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity

AM Khaliq, M Rajamohan, O Saeed, K Mansouri… - Nature Genetics, 2024 - nature.com
… By applying spatially resolved transcriptomics to matched primary and metastatic PDAC …
immunosuppressive spatial ecotypes across anatomical regions. We observed spatial tumor …

Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma

R Moncada, M Chiodin, JC Devlin, M Baron, CH Hajdu… - BioRxiv, 2018 - biorxiv.org
… , the characterization of their spatial organization within it has been more elusive. The
recently introduced ‘spatial transcriptomics’ method (ST) reveals the spatial pattern of gene …

Single-nucleus RNA-seq and Spatial Transcriptomics of Archival Primary Pancreatic Ductal Adenocarcinoma Uncovers Multi-compartment Intratumoral Heterogeneity …

W Hwang, K Jagadeesh, JA Guo… - International Journal of …, 2020 - redjournal.org
spatial transcriptomics. Our results reveal important biological insights that have direct
implications on the treatment of PDAC. We are using our data to deconvolve cell type proportions …

… ‐cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid …

T Zhan, Y Zou, Z Han, XR Tian, M Chen… - Clinical and …, 2024 - Wiley Online Library
Aim The main focus of this study is to explore the molecular mechanism of IRF7 regulation
on RPS18 transcription in M1‐type macrophages in pancreatic adenocarcinoma (PAAD) …

Spatial Transcriptomics of Intraductal papillary mucinous neoplasms of the Pancreas identifies Nkx6-2 as a driver of gastric differentiation and indolent biological …

M Sans, Y Makino, J Min, KI Rajapakshe… - Cancer discovery, 2023 - AACR
Identification of the molecular features driving IPMN development and differentiation is critical
to prevent cancer progression and enhance risk stratification. We used spatial profiling to …