Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer
Z Peng, M Ye, H Ding, Z Feng, K Hu - Journal of Translational Medicine, 2022 - Springer
… previously published spatial transcriptomics (ST) data and profiled a spatial atlas of TME …
In detail, we combined spatial transcriptomics with ssGSEA to precisely identify different cell …
In detail, we combined spatial transcriptomics with ssGSEA to precisely identify different cell …
Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma
… , the characterization of their spatial organization within it has been more elusive. The
recently introduced ‘spatial transcriptomics’ method (ST) reveals the spatial pattern of gene …
recently introduced ‘spatial transcriptomics’ method (ST) reveals the spatial pattern of gene …
Exploring tissue architecture using spatial transcriptomics
… surveys, the large-scale atlases generated by this technology lend … Here we review spatial
transcriptomic technologies and … The use of spatial transcriptomics to generate spatial atlases …
transcriptomic technologies and … The use of spatial transcriptomics to generate spatial atlases …
Spatial transcriptomics technology in cancer research
… In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
Estimation of cell lineages in tumors from spatial transcriptomics data
… Spatial transcriptomics (ST) technology through in situ capturing has enabled topographical
gene expression profiling of tumor tissues. … Cell type deconvolution in tumor ST data remains …
gene expression profiling of tumor tissues. … Cell type deconvolution in tumor ST data remains …
Integration of pan-cancer single-cell and spatial transcriptomics reveals stromal cell features and therapeutic targets in tumor microenvironment
Y Du, J Shi, J Wang, Z Xun, Z Yu, H Sun, R Bao… - Cancer Research, 2024 - AACR
… To establish a single-cell transcriptome atlas of human stromal cells, we collected 306
primary patient tumors and 122 adjacent normal tissues spanning 16 cancer types from public …
primary patient tumors and 122 adjacent normal tissues spanning 16 cancer types from public …
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
… spatial organization remains challenging. We combine a microarray-based spatial transcriptomics
method that reveals spatial … Such ISH atlases used for tissue with defined morphology …
method that reveals spatial … Such ISH atlases used for tissue with defined morphology …
The web-based portal SpatialTME integrates histological images with single-cell and spatial transcriptomics to explore the tumor microenvironment
… The intercellular interactions in the TME contribute to tumor initiation, progression, … spatial
transcriptomics (ST) have revolutionized the molecular understanding of the TME at the spatial …
transcriptomics (ST) have revolutionized the molecular understanding of the TME at the spatial …
Spatial transcriptomics in health and disease
S Jain, MT Eadon - Nature Reviews Nephrology, 2024 - nature.com
… the generation of comprehensive molecular atlases, and provide … of current and emerging
spatial transcriptomic methods, their … In addition to atlas-building efforts, spatial transcriptomics …
spatial transcriptomic methods, their … In addition to atlas-building efforts, spatial transcriptomics …
Comprehensive analysis of bulk, single-cell RNA sequencing, and spatial transcriptomics revealed IER3 for predicting malignant progression and immunotherapy …
Q Wang, C Zhang, Y Pang, M Cheng, R Wang… - Cancer Cell …, 2024 - Springer
… Samples in the high IER3 subgroup were characterized by increased infiltration of tumor-associated
monocytes/macrophages (TAMMs), as well as the elevated sensitivity to Dabrafenib, …
monocytes/macrophages (TAMMs), as well as the elevated sensitivity to Dabrafenib, …
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