… species (4-9). Although several forms of carboxylesterases have been purified from various
species, there is little understanding of their enzymatic similarities and differences because a …

… the carboxylesterase activity. In conclusion, liver microsomal carboxylesterase in mammals
and humans … that the iso zymes from various species examined here showed considerable …

… species and tissue differences. In the present study, we performed the kinetic analyses in
humans and rats in order to clarify these differences. … kinetics in human liver microsomes (HLM) …

… Species differences exist in the expression and distribution of CEs, and this may impact the
extrapolation of animal studies to humans. For example, rats and mice, the two most widely …

… the carboxylesterase activity. In conclusion, liver microsomal carboxylesterase in mammals
and humans … that the isozymes from various species examined here showed considerable …

… Between species differences of hydrolase activity in small intestine and liver result in …
species, including humans. Therefore, the effect and toxicity of ester-type xenobiotics in humans …

… Recently, we have studied various aspects of carboxylesterases using cDNAs of carboxylesterase
isozymes purified from 9 animal species and human liver microsomes, and found that …

… species differences in CES tissue distribution and catalytic activity are particularly challenging
in human … , MR Crystal structures of human carboxylesterase 1 in covalent complexes with …

… ubiquitous in all species, but were highly expressed in primates and dogs, whereas
carboxylesterase (CES) … These differences in plasma esterases and their expression levels result …

… This study could provide new insights for the species differences between dogs and humans,
which should be received attention in drug pharmacokinetics and toxicological studies. …