CIRI: an efficient and unbiased algorithm for de novo circular RNA identification

Y Gao, J Wang, F Zhao - Genome biology, 2015 - Springer
… The expression of a specific circRNA type is represented by the count of junction reads
normalized by total sequencing amount in each cell type. The boxplot is generated by R using ln(…

Intriguing circles: conflicts and controversies in circular RNA research

HM Li, XL Ma, HG Li - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
… ability is not a general circRNA phenomenon and might be limited to specific circRNAs.
To be a better miRNA sponge, the result of the formula circRNA molecules × miRNA binding …

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

P Li, S Chen, H Chen, X Mo, T Li, Y Shao, B Xiao… - Clinica chimica acta, 2015 - Elsevier
… These results suggested that circRNAs are highly stable in mammalian cells and that one
specific circRNA, hsa_circ_002059, may be a potential novel and stable biomarker for the …

The biogenesis and emerging roles of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2016 - nature.com
… -seq and specific computational pipelines that aim to identify reads spanning the back-…
to be highly expressed in a cell type-specific or tissue-specific manner 16,17 . Furthermore, …

A map of human circular RNAs in clinically relevant tissues

PG Maass, P Glažar, S Memczak, G Dittmar… - Journal of molecular …, 2017 - Springer
… By identifying and validating selected circRNAs in these human tissues relevant to clinical
research, we provide multiple examples of abundant and highly tissue-specific circRNA

Context-specific effects of sequence elements on subcellular localization of linear and circular RNAs

M Ron, I Ulitsky - Nature communications, 2022 - nature.com
… of specific RNA … of circular RNAs; SAFB binding is associated with nuclear enrichment
of predominantly unspliced linear RNAs; and IGF2BP1 promotes export of linear spliced RNA

Structured elements drive extensive circular RNA translation

CK Chen, R Cheng, J Demeter, J Chen… - Molecular cell, 2021 - cell.com
The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …

Circular RNAs: a novel class of functional RNA molecules with a therapeutic perspective

L Santer, C Bär, T Thum - Molecular Therapy, 2019 - cell.com
… We summarize different molecular mechanisms of action and highlight circRNAs with
specific roles in cardiovascular disease. Finally, we describe a number of tools for …

Circular RNA: an emerging non-coding RNA as a regulator and biomarker in cancer

B Chen, S Huang - Cancer letters, 2018 - Elsevier
… TSCD (http://gb.whu.edu.cn/TSCD/ ) provides a global view of tissue-specific circRNA in
the tissues of humans and mice and is able to contribute to identifying new markers for …

[HTML][HTML] Cell type-specific circular RNA expression in human glial cells

A Curry-Hyde, LG Gray, BJ Chen, U Ueberham… - Genomics, 2020 - Elsevier
… The circular transcriptome of human glial cells is an area of … Circular RNAs (circRNAs)
have the potential to facilitate the … RNA-seq data utilized in this paper are suitable for circRNA