Mass spectrometry imaging of pharmacological compounds in tissue sections

RJA Goodwin, AR Pitt - Bioanalysis, 2010 - Future Science
… periods to the field of pharmacology and biomarker imaging research. By collecting spectra
Compound and metabolite distribution measured by MALDI mass spectrometric imaging in …

Mass spectrometry imaging in drug development

A Nilsson, RJA Goodwin, M Shariatgorji… - Analytical …, 2015 - ACS Publications
… technologies are superior to established methods for studying compound localization and …
through the BBB in order to exert their pharmacological effects, and treatment failures in these …

Drug compound characterization by mass spectrometry imaging in cancer tissue

HJ Kwon, Y Kim, Y Sugihara, B Baldetorp… - Archives of pharmacal …, 2015 - Springer
pharmacological activities of the drug. The potentially beneficial or toxic effects of such drug
therapy are determined by the unique chemical and pharmacologicalspectrometry imaging (…

Spatial pharmacology using mass spectrometry imaging

P Rajbhandari, TV Neelakantan, N Hosny… - … in Pharmacological …, 2024 - cell.com
… This is enabled by mass spectrometry imaging (MSI) that … potential of comprehensive spatial
pharmacology through integration of … improving reproducibility and compound annotation to …

Mass spectrometry imaging: new eyes on natural products for drug research and development

J Hou, Z Zhang, W Wu, Q He, T Zhang, Y Liu… - Acta Pharmacologica …, 2022 - nature.com
imaging technologies can detect thousands of compounds simultaneously on a label-free
basis. Over the last two decades, mass spectrometry imaging … distribution and pharmacological

Mass spectrometric imaging of small molecules

A Svatoš - Trends in biotechnology, 2010 - cell.com
… The compounds are introduced to spectrometers directly, or … ), to allow mixtures of compounds
to be separated before mass … A more advanced way to confirm compound identity and to …

Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance

M Jove, J Spencer, M Clench, PM Loadman… - Critical reviews in …, 2019 - Elsevier
… the tumour, “precision pharmacology” techniques are needed. Mass spectrometry imaging
(MSI) is a relatively new and complex technique that allows imaging of drug distribution within …

Future technology insight: mass spectrometry imaging as a tool in drug research and development

DF Cobice, RJA Goodwin, PE Andrén… - … of Pharmacology, 2015 - Wiley Online Library
… , pharmacodynamics and transport properties of compounds in tissues is crucial … spectrometry
imaging (MSI) can discriminate drug and its metabolites and endogenous compounds

Innovation in drug toxicology: Application of mass spectrometry imaging technology

H Jiang, S Gao, G Hu, J He, H Jin - Toxicology, 2021 - Elsevier
… mass spectrometry imaging (MSI) technology can overcome the above limitations and provide
relative abundance information of compounds … , and the pharmacological or toxicological …

[HTML][HTML] The application of mass spectrometry imaging in traditional Chinese medicine: a review

L Huang, L Nie, Z Dai, J Dong, X Jia, X Yang, L Yao… - Chinese Medicine, 2022 - Springer
… traditional Chinese medicine, discover new compounds from traditional herbs, and differentiate
… Moreover, mass spectrometry imaging also plays a role in revealing the pharmacological