… Results of the immunohistochemical analyses revealed that embryonic stem cell markers
increased following the differentiation of CSCs when the cells constituted a spheroid formation. …

… this cell-to-cell signaling… spheroids in serum-free medium supplemented with specific growth
factors. As a result of asymmetric stem cell division spheroids were enriched in cancer stem …

… cultured MSCs; however, a critical lack of understanding exists with relation to the
molecular signaling mediating the enhanced MSC spheroid properties or the improved …

… Spheroid stem cell cultures promote the expression of transcriptional factors of stemness
markers such as Oct-4 and Nanog (Table 2). Spheroid stem cells … facilitates cellular signal …

… cellular characteristics and possible molecular signaling transduction pathways of human
DPSCs cultured as 3DM-spheroids … the formation of 3D-aggregates and 3DM-spheroids was …

… and spheroid formation and induced apoptosis in malignant cells … stem cell-associated
signaling To elucidate the effect of long-term cabozantinib treatment to CSC-associated signaling …

… intercellular adhesion and the canonical Wnt signaling pathway. Supporting this model,
we … spheroid formation and causes disassembly of preexisting spheroids into single cells, …

… entrapment of MSC spheroids formed from osteogenically induced cells would exhibit better
… -forming potential than would dissociated cells from monolayer culture. Spheroids exhibited …

… In addition, to explore the role of signaling pathways in the spheroid formation, the NF-κB
activator lipopolysaccharide (LPS, 100 ng/mL), PI3K inhibitor S14161 (20 μg/mL), or AKT …

… As such, Hh pathway mediators are likely important in the cancer stem cell property of spheroid
formation. Of note, was the correlation of up/down-regulation of GLI1 (monolayer to SFCs…