Protective effects of Indian spice curcumin against amyloid-β in Alzheimer's disease

PH Reddy, M Manczak, X Yin… - Journal of …, 2018 - content.iospress.com
… Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD)
pathogenesis. Natural products, such as ginger, curcumin, … and synthesized curcumin and its …

The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture

JB Hoppe, RL Frozza, ENS Pires… - Neurological …, 2013 - Taylor & Francis
Curcumin, the curry flavoring and coloring agent, is the principal curcuminoid constituent of
the spice turmeric… been carried out to investigate the pharmacological properties of curcumin. …

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse

GP Lim, T Chu, F Yang, W Beech… - Journal of …, 2001 - Soc Neuroscience
… In this study, we report that the Indian spice curcumin suppresses indices of inflammation and
… , nontoxic doses of curcumin decrease levels of insoluble and soluble amyloid and plaque …

A potential role of the curry spice curcumin in Alzheimer's disease

JM Ringman, SA Frautschy, GM Cole… - Current Alzheimer …, 2005 - ingentaconnect.com
… The low blood levels of curcumin seen in this study and the absence of curcumin seen with
… of curcumin in the intestinal wall and/or poor absorption. The possibility that curcumin is …

[HTML][HTML] … of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ …

A Maugeri, C Russo, GT Patanè, D Barreca… - Molecules, 2023 - mdpi.com
spice blend composed of a combination of cinnamon, Cinnamomum cassia (bark) and two
different root extracts of turmeric, Curcuma … benefits of cinnamon and curcumin/turmeric [20,21]…

Curcumin and curcumin-like molecules: from spice to drugs

A Marchiani, C Rozzo, A Fadda… - Current medicinal …, 2014 - ingentaconnect.com
… Abstract: Curcumin is the major yellow pigment extracted from turmeric, a commonly used
spice in Asian … A number of studies have shown that curcumin can be a prevention and a …

[HTML][HTML] Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein

C Zhang, A Browne, D Child, RE Tanzi - Journal of Biological Chemistry, 2010 - ASBMB
amyloid-β precursor protein (APP). Curcumin is a compound in the widely used culinary
spice… We show for the first time that curcumin potently lowers Aβ levels by attenuating the …

PPARγ agonist curcumin reduces the amyloid-β-stimulated inflammatory responses in primary astrocytes

HM Wang, YX Zhao, S Zhang, GD Liu… - Journal of …, 2010 - content.iospress.com
Curcumin is the active ingredient in the traditional herbal remedy and dietary spice
turmeric (Curcuma longa). The treatment with curcumin in amyloid-β protein precursor (AβPP) …

[HTML][HTML] Curcumin alters the salt bridge-containing turn region in amyloid β (1–42) aggregates

VS Mithu, B Sarkar, D Bhowmik, AK Das… - Journal of Biological …, 2014 - ASBMB
Amyloid β (Aβ) fibrillar deposits in the brain are a hallmark of Alzheimer disease (AD).
Curcumin, a common ingredient of Asian spices, is known to disrupt Aβ fibril formation and to …

[HTML][HTML] Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer's disease brains: Implications for in-vivo diagnostics

J den Haan, THJ Morrema, AJ Rozemuller… - Acta neuropathologica …, 2018 - Springer
… The combined fluorescent and Aβ-binding properties of the dietary spice curcumin could
yield diagnostic purpose in the search for a non-invasive Aβ-biomarker for Alzheimer’s disease (…