Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants
… Antibodies are key components of the human immune system’s response to SARS-CoV-2,
and the spike protein is a prime target of neutralizing antibodies (nAbs) as it plays critical …
and the spike protein is a prime target of neutralizing antibodies (nAbs) as it plays critical …
Evaluation of spike protein antigens for SARS-CoV-2 serology
S Jagtap, K Ratnasri, P Valloly, R Sharma… - Journal of Virological …, 2021 - Elsevier
… Our results show that the antibody response in humans is consistent among the spike
antigens, and the spike trimer maybe the best choice of antigen for COVID-19 serology. …
antigens, and the spike trimer maybe the best choice of antigen for COVID-19 serology. …
[HTML][HTML] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
… cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter
… Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited …
… Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited …
[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape
… In this Review, we summarize the literature on mutations of the SARS-CoV-2 spike protein,
the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the …
the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the …
The spike of concern—the novel variants of SARS-CoV-2
A Winger, T Caspari - Viruses, 2021 - mdpi.com
… While inter-person transmission becomes therefore more likely, neither disease progression
nor neutralization by anti-spike antibodies are significantly affected by the D614G mutation […
nor neutralization by anti-spike antibodies are significantly affected by the D614G mutation […
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
B Isho, KT Abe, M Zuo, AJ Jamal, B Rathod… - Science …, 2020 - science.org
… antibodies remained relatively stable up to 105 days PSO in both biofluids. Lastly, IgG, IgM
and to a lesser extent IgA responses to spike … and saliva IgG antibodies to SARS-CoV-2 are …
and to a lesser extent IgA responses to spike … and saliva IgG antibodies to SARS-CoV-2 are …
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… of RBD-based spike antigen for reliable detection of SARS-CoV-2–specific antibodies. We
produced properly folded RBD from the spike proteins of SARS and common cold HCoVs in …
produced properly folded RBD from the spike proteins of SARS and common cold HCoVs in …
[HTML][HTML] Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation
… In addition to documenting the emergence of SARS-CoV-2 Spike ΔH69/ΔV70 in vivo, we
show that this mutation increases infectivity of the Spike protein in a pseudotyping assay. The …
show that this mutation increases infectivity of the Spike protein in a pseudotyping assay. The …
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits
S Ravichandran, EM Coyle, L Klenow, J Tang… - Science translational …, 2020 - science.org
… protein–based vaccines, we performed a qualitative study by immunizing rabbits with
various SARS-CoV-2 spike protein antigens: S ectodomain (S1+S2; amino acids 16 to 1213), …
various SARS-CoV-2 spike protein antigens: S ectodomain (S1+S2; amino acids 16 to 1213), …
Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies
… Interestingly, SARS-CoV infects cells that express ABH antigens according to the individual's
ABO phenotype. Indeed, SARS-CoV infection has been documented in pneumocytes, …
ABO phenotype. Indeed, SARS-CoV infection has been documented in pneumocytes, …
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