Spina bifida: the significance of the level and extent of the defect to the morphogenesis

AJ Barson - Developmental Medicine & Child Neurology, 1970 - Wiley Online Library
… It is perhaps understandable that our knowledge of the morbid anatomy of spina bifida is …
-that is, pedicular and laminar splaying-at the corresponding levels of the axial skeleton. No …

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

MR Brouns, SCP De Castro… - Human molecular …, 2011 - academic.oup.com
… isolated spinal NTDs (spina bifida) occur in fewer models, despite being common human
birth defects. Spina bifida occurs at high frequency in the Axial defects (Axd) mouse mutant but …

Spina bifida

AJ Copp, NS Adzick, LS Chitty, JM Fletcher… - Nature reviews Disease …, 2015 - nature.com
… A strong correlation is apparent between the axial level of lesion and the degree of disability
… The main brain defects involve the range of anomalies related to the Chiari II malformation …

The diagnostic features of spina bifida: the role of ultrasound

BG Coleman, JE Langer, SC Horii - Fetal diagnosis and therapy, 2015 - karger.com
… In addition to localization of the conus medullaris and spinal defects, … b Axial image of osseous
defect at L2 with tethered cord (… c Axial image of skin defect at L4 (arrow) with anomalous …

Spina bifida: pathogenesis, mechanisms, and genes in mice and humans

SW Mohd-Zin, AI Marwan, MK Abou Chaar… - …, 2017 - Wiley Online Library
Spina bifida is among the phenotypes of the larger condition known as neural tube defects
(… leading cause of birth defects after congenital heart defects. In this review paper, we define …

Spina bifida

LE Mitchell, NS Adzick, J Melchionne, PS Pasquariello… - The Lancet, 2004 - thelancet.com
… portion of the spinal cord is formed … Spina bifida (meningomyelocoele) is a defect of primary
neurulation that results from failure of fusion in the caudal region of the neural tube. Defects

Congenital vertebral anomalies: aetiology and relationship to spina bifida cystica.

R Wynne-Davies - Journal of medical genetics, 1975 - jmg.bmj.com
… Some index patients must have had congenital vertebral defects in addition to spina bifida but
how … Developmental anomalies unrelated to the axial skeleton and spinal cord defect were …

Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?

AJ Copp, FA Brook - Journal of medical genetics, 1989 - jmg.bmj.com
… is associated with male ct/ct embryos as in humans and, second, to find the precise axial
level of spina bifida in ct/ct mouse embryos at various stages of gestation, in order to determine …

[PDF][PDF] Spina Bifida: Morphological Features, Molecularegulations and Signal Pathways

HK Basaloglu, S Celik, KD Kilic, T Cavusoglu… - J Spine, 2017 - academia.edu
… The main aim of this article is to review the knowledge about the closure defect of the vertebral
column calls spina bifida. The anatomic, embryologic and molecular biologic knowledge …

Spina bifida occulta in homozygous Patch mouse embryos

J Payne, F Shibasaki, M Mercola - … Dynamics: An Official …, 1997 - Wiley Online Library
spina bifida involving the entire spinal column. We have analyzed the progression of the axial
defects in … of the neural arch condensation at all axial levels. Furthermore, since the neural …